A specific indicator may help develop new treatments for HIV

Recently, scientists from George Mason University in the United States identified a special indicator through research, which may help develop new treatments for HIV The relevant research is published in the research report in the international journal Science advanced In this paper, researchers focus on a protein called coilin, which can regulate cell mobilization and resist the mechanism of infection In HIV infected patients, fibroin dysfunction is a key factor in the defect of helper T cells Helper T cells can enhance the immune response of the body by recognizing exogenous antigens and helping the immune system react Although it can not provide a complete treatment and can not completely restore the function of the immune system of patients, antiretroviral therapy can significantly increase the life span of HIV infected people The natural process of HIV infection often leads to the occurrence of multiple immune defects in patients, including the damage of T cell migration The researchers found that compared with healthy individuals (http://www.chemdrug.com/article/7/), the phosphorylation level of fibroin in the body of HIV infected people will significantly decrease, and the phosphorylation process of fibroin can control the activity of fibroin at the same time of phosphorylation Silk cut protein is a key protein, which can help cells generate the driving force of migration, and the appropriate phosphorylation of silk cut protein is very important for cell migration in and out of tissues The results of this study show that antiretroviral therapy alone seems unlikely to achieve long-term control of HIV, because it is not enough to repair the functional damage of silk cut protein caused by HIV infection, and it can not restore the migration process of normal T cells The researchers point out that stimulation of T cells (such as the antibody to α 4 β 7 integrin) by additional therapy can regulate the activity level of silk cut protein and restore the movement characteristics of T cells This therapy can provide lasting immune control for simian immunodeficiency virus (SIV), but it does not seem to have such effect in HIV infected human patients In this study, researchers identified a new target (fibroin) Later, they hope to develop a functional therapy that can repair the immune damage of HIV patients and completely cure HIV through more in-depth research.