A study by the University of Pennsylvania has shown that glowing dyes can help doctors remove cancer cells.

This article is original and reprinted by Cathy. Introduction: "clearing the edge" is the goal of cancer resection.even if a small piece of cancer tissue is left over, it will increase the possibility of local recurrence and disease spread, which may shorten the survival time of patients.recently, researchers from the University of Pennsylvania used a dye that glows in near-infrared light and preferentially accumulates in cancer cells, which will help doctors remove tumor tissue completely.scientists at the University of Pennsylvania have developed a technique that can help surgeons see clearly if they have left any diseased tissue.they used a dye that glows in near-infrared light and preferentially accumulates in cancer cells to undergo mastectomy on dogs treated in veterinary hospitals.the study was led by David Holt of the Department of clinical science and advanced medicine, School of veterinary medicine, University of Pennsylvania and published in the public library of science.the title is "intraspecific near infrared imaging can identify Cannine mammary tubes, a spontaneously occurring, The researchers used indocyanine green (ICG), an FDA approved contrast agent, which fluoresces under near-infrared light and tries to distinguish normal tissue from cancer tissue in different types of cancer.scientists believe that the accumulation of ICG in cancer cells is due to its ability to penetrate through the rapidly growing blood vessels in tumors, which are often more permeable than normal blood vessels in healthy tissues.they found that this technique not only makes tumors emit fluorescence, but also makes cancer cells that spread to lymph nodes also glow.breast cancer in dogs is similar to human breast cancer in many key aspects.the team believes that the use of a parallel technique of different dyes targeting cancer cells can improve the prognosis of breast cancer patients who choose breast conserving surgery.the study's corresponding author David Holt said: "there are two main benefits to doing this kind of research. On the one hand, dogs are a good model of human breast cancer, and on the other hand, the study does benefit dogs."the objective of the current study is to test the technique in pet dogs with breast cancer as a model for breast conserving surgery in women.all dog owners agreed to participate in the study.the day before the operation, the dog received ICG injection.the operation itself, whether mass resection or mastectomy, is carried out according to the standard nursing procedures.then, under near-infrared light, the surgeon observed the tumor and the surgical site, looking for the luminous ICG signal. in dogs, because aesthetic issues are not so important, surgeons usually remove breast tumors with a much wider margin than those with breast conserving surgery on humans. therefore, no residual "dirty edges" were detected after resection. however, they found that larger tumors accumulated more dye. the team was also interested in dog lymph nodes. Holt said: "for women with breast cancer and dogs with breast cancer, if the cancer cells have spread to the lymph nodes, this technique will help patients' prognosis. studies have shown that we can identify draining and metastatic lymph nodes. "in human medicine, radioisotopes injected into the breast are usually used to identify draining or sentinel lymph nodes. the use of intravenously injected near-infrared imaging agents means that radioactive agents and protective shielding are no longer required. Holt also said: "if we can inject before surgery and only identify potentially problematic lymph nodes, we can avoid the risk of removing too many lymph nodes or leaving those with metastatic diseases. "in the follow-up work, Holt and his colleagues at Penn State Medical College will continue to study the effectiveness of targeted near-infrared imaging agents in cancer patients. these dyes bind more specifically to cancer cells and help to better define the "clearance margin" of human and canine cancer patients. Ref.: [1] Newton a, predina J, mison m, et al. (2020) intraspecific near infrared imaging can identify Cannine mammary tubes, a spontaneously occurring, Large animal model of human breast cancer. PLoS One 15 (6): e0234791. [2] [3] recommended reading: fight the epidemic situation, translational medicine network content team series report: [breakthrough] scientists of the three countries jointly developed a new "detoxification version" of erythromycin, and the side effects were greatly reduced! [PNAs] Yale University Research! The switch to control the inflammation caused by overeating has been found! [new findings] black raspberries, or a new "Star" in reducing skin inflammation, can damage arteries and increase the risk of heart disease, according to Ohio State University research