A well-known Chinese scholar published an article: Gene expression mechanisms related to immunity and cancer

Selective polyadenylation (APA) is an RNA processing mechanism that regulates gene expression by producing different ends on the RNA transcript of the same gene

Dr.

After gene transcription, messenger RNA is chemically modified to become mature RNA molecules that can leave the nucleus and perform their functions

Through APA, a gene can be polyadenylated at multiple sites, resulting in mRNA having different coding sequences and/or regulatory regions (3' untranslated regions or 3'utr), called subtypes

Tian and colleagues used functional genomics to analyze the distribution of APA subtypes in mouse cells

They named this mechanism the translation-independent ER association (translation-independent ER association, TiERA, Biological General Note), and found that some mRNAs have specific sequences and structures, which determine their occurrence of APA and The potential ultimately associated with the endoplasmic reticulum

Professor Tian said: “When mRNA leaves the nucleus and transfers to the cytoplasm, they need to be correctly guided to the appropriate location for protein translation

The research team found that mRNAs with higher TiERA tend to encode signal proteins that respond to changes in the environment by sending, receiving, and processing signals to help cells communicate with each other

They proposed that APA makes this process more effective by anchoring specific ER mRNA subtypes at specific cellular locations where important signaling events occur

Professor Tian said: "According to our model, the endoplasmic reticulum can be used as a scaffold to store proteins where it is most needed

(Biocom)

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