Absorption and metabolism of citrus flavonoids and limonoids

2015-02-03 classification: efficacy 0 people commented on the absorption and metabolism of bioactive substances (mainly flavonoids and limonoids) from citrus, which is a contrast with the current people's attention to them Naringenin is the ligand and a metabolite of naringenin Recently, Hsiu et al (2002) took rabbits as experimental subjects, and compared the pharmacokinetics of naringin and naringin by intravenous or oral administration The results showed that there were significant differences in the pharmacokinetics between naringin and naringin Compared with oral naringin, the absorption rate and the maximum concentration of naringin were slower, but its retention time in blood was longer than oral naringin After oral administration of naringin, the main component of m-qing was naringin ligand gluconic acid, but only a small amount of naringin ligand (free Type) It can be seen that in the study of the physiological activities of flavonoids in vivo, we should not focus too much on their gametophytes or ligands, but on the biological activities of their conjugated metabolites Miyake et al (1997) studied the initial metabolism of citronelloside in vivo after ingestion, and found that intestinal bacteria can degrade it Among them, Bacteroides bacteria can remove citronelloside and generate citronellol, which is reduced to phloroglucinol and 3,4 - = hydroxy dehydrocinnamic acid (DHCA) by the action of clostridirtrn butyricunz bacteria In addition, the scholar not only used linoleic acid and rabbit red blood cell membrane matrix system to measure the antioxidative effect of citricoside metabolites, but also carried out an in vitro inhibition experiment of LDL oxidation It was confirmed that citricoside and its metabolites inhibited LDL oxidation better than tocopherol The results showed that citricoside still had strong activity after intestinal bacterial metabolism Furthermore, it can be concluded that most of the flavonoids in Citrus still show strong biological activity in intestinal bacterial metabolism Therefore, they are expected to show more physiological functions in the body Manners et al (2003), an American scholar, used lc.ms analysis technology to analyze four groups of healthy men and women (four in each group) In order to study the absorption, metabolism and bioavailability of Citrus limonoids in human body, a high-dose experiment was carried out The results of plasma analysis showed that with the increase of the dose of limonoids, the average maximum concentration of limonoids in plasma increased from 1.74 nmol / L to 5.27 nmol / L, respectively However, it was observed in different populations that the concentration of lemon bitterness was significantly different It can be seen from this study that: ① limonoside can be absorbed and metabolized by the human body, and its metabolites still have considerable bioavailability to the human body; ② the effective limonoids in different populations vary greatly, which is closely related to their living habits, eating habits and health conditions.