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Academician Shang Yongfeng's team discovered the key role of LSD1 in DNA replication

 Last Update: 2022-05-19
 Source: Internet
 Author: User

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On April 13, 2022, the team of Academician Shang Yongfeng from Peking University School of Basic Medicine published a research paper titled "LSD1 is required for euchromatic origin firing and replication timing" online in Signal Transduction and Targeted Therapy

The working mode of LSD1 regulating euchromatic DNA replication

Eukaryotic DNA replication involves complex replication initiation regulatory mechanisms to ensure that the genome is replicated only once during a cell cycle

LSD1 is highly expressed in different types of cancer, including bladder and colorectal cancers, estrogen receptor-negative breast and prostate cancers,

Shang Yongfeng and Yang Xiaohan of Peking University School of Basic Medicine are the co-corresponding authors of the paper, and postdoctoral fellow Wang Yue is the first author of the paper

Original link: https:// University School of Basic Medicine)

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