ACS Sub-Journal: Asthma Drugs Can Cure Alzheimer's

, March 20, 2020 /PRNewswire/ --- A new study suggests that the common asthma drug salbutamol may offer the potential to treat Alzheimer's diseaseAlzheimer's disease is the most common form of dementia, affecting 47 million people worldwide, and is expected to triple to 130 million cases by 2050No effective cure or slows its progression has been identifiedHowever, this new early study shows that the re-use of the existing drug salbutamol has great potential for low cost and rapid response(photo source:the study, led by researchers at Lancaster University, used a new automated "high-throughput" screening method to study the structure of misfolded tau proteins using a special analytical techniqueWith this powerful technology, they were able to simultaneously view more than 80 existing compounds and drugs to screen their effectiveness in preventing tau fiber formationextensive in vitro analysis experiments have shown that salbutamol is effective in reducing the accumulation of insoluble fiber in tau proteins, which are common lying in the brains of Alzheimer's patientsThese microscopic fibers accumulate into neurogenal fibrosis, which can lead to neuronal instability, brain cell death, and are a key feature of disease progressionmethod confirms the effectiveness of epinephrine in stabilizing tau proteins and preventing tau entanglementHowever, our bodies do not absorb epinephrine easily, and it metabolizes quickly, so the scientists then studied a series of off-the-shelf compounds with similar chemical structures, including salbutamolfurther testsusing a variety of analytical techniques have shown that salbutamol inhibits tau aggregation in vitroAdding salbutamol to a solution containing tau results in a significant reduction in the density of tau structural fibers responsible for tau neurogenic fiber tangledresearchers believe that salbutamol interacts with the early stages of the formation of tau fibers, reducing their ability to form the initial nucleus, thus driving the aggregation processhas the potential to treat Alzheimer's disease because salbutamol is easily ingested, absorbed into the brain and kept in the body for several hours(Bio Valley Bioon.com) source: Study Shows drug salbutamol's salbutamol's original source of : David J Townsend et al, Circular dichroism specscopys the beta-
adrenostor gogstnith salbutamol DOI: 10.1021/acschemneuro.0c00154