Acta Neuropathologica: Genome-wide DNA methylation spectrum distinguishes between silent and non-silent ACTH adenomas.

!---- the expression of adrenal corticosteroid synodoid hormone (ACTH), which can lead to Cushing disease (CD)expression of ACTH but not too much cortisol, ACTH adenomas (SCA) may exhibit more aggressive courses and are currently classified as "invasive pituitary adenomas" according to the WHO classificationHowever, SCA and CD can only be distinguished by a wide range of endocrine tests, which are usually ambiguous and may include subclinical CDsthe authors analyzed tumor samples from patients with heliosis-confirmed ACTH adenomas to detect DNA-based methylation subgroups that predicted the patient's clinical phenotype23 patients had no clinical symptoms (SCA), while 49 patients had endocrine-proven CDs, sCA patients had significantly larger tumors with MRI measurementswith regard to DNA methylation, the use of pairs of Pearson correlation coefficients for all samples were clustered without supervision, and CD and SCA were distinguished into two separate clusters, while the third group was heterogeneous in their clinical manifestationsUSP8 mutation is only found in CDs, but GATA3 expression is only present in SCA cases(t-SNE) further supports the distinction between SCA and CD by their epigenetic characteristicsResults: The authors' data also suggest that the unique tumor pathogenesis of CD and SCA adenomas has a potential "intermediate state"clinical manifestations of subclinical CD, but in neuropathology can not be separatedauthors' data suggest that genome-wide DNA methylation can group SCA and CD adenomas, which may not be possible by standard endocrinology tests or histopathologyoriginal link to Ricklefs, F.L., Fita, K.D., Rotermund, Ret alGenome-wide DNA methylation profiles s r silent from-non-silent ACTH.d'adenomasActa Neuropathol 140, 95-97 (2020)MedSci Original Source: MedSci Original !-- Content Presentation Ends - !-- Determine Stocing End s--