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Acta Neuropathologica: Neuron-specific activation of cortical gray matter necrosis signals in multiple sclerosis

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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The pathological features of the progressive stage of multiple sclerosis (MS) are the accumulation of chronic demyelinating lesions in the white matter (WM), variable axonal damage and loss in WM, diffuse changes in the normally occurring WM, and Increased cortical gray matter pathology.

This article describes the increased expression of multiple steps in the TNF/TNF receptor 1 signaling pathway leading to necrosis through 28 cases of secondary progressive MS patients and 10 non-neurological disease controls after death.

In contrast, caspase-8-dependent apoptotic signal transduction is reduced.

The density of phosphorylated MLKL+ neurons was negatively correlated with age of death, age of progression, and duration of disease.

The research data in this article shows that the neurons in the MS cortex die through necrosis stimulated by TNF/TNFR1 instead of apoptosis, which may be partly caused by chronic meningeal inflammation.

Neurons in the MS cortex die through necrosis stimulated by TNF/TNFR1 instead of apoptosis, which may be partly caused by chronic meningeal inflammation.

Picon, C.
, Jayaraman, A.
, James, R.
et al.
springer.
com/article/10.
1007/s00401-021-02274-7" target="_blank" rel="noopener">Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter.
springer.
com/article/10.
1007/s00401-021-02274-7" target="_blank" rel="noopener"> Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter.
Acta Neuropathol 141,585 –604 (2021).
Leave a message here springer.
com/article/10.
1007/s00401-021-02274-7" target="_blank" rel="noopener"> springer.
com/article/10.
1007/s00401-021-02274-7" target="_blank" rel="noopener">

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