Acta Neuropathologica: The cause of stage dependence for re-myelinization of multiple sclerosis.

Multiple sclerosis (MS) is the most common inflammatory and demyelinated disease in the central nervous system and is a major cause of disability in young people.
affects about 2.3 million people worldwide, and about 50 percent of patients need a walkman 10-15 years after being sick.
In histopathology, multiple sclerosis is characterized by multiple lesions of demyelination, inflammatory immersion (macrophages, T-cells and B-cells), axon damage and reduced number, and less protrusion glial cell loss.
, despite significant advances in immunotherapy in recent years, progress in the disease remains unsuppressed.
re-myelin refers to the formation of a new myelin after demyelination, which may fail in multiple sclerosis.
the differentiation of progenitic cells to myelin-less-protruding glial cells may be the cause of the failure of re-myelinization, therefore, the development of pharmacological methods to promote the differentiation of myelin cells and myelin re-formation represents a promising new treatment.
, however, this generally accepted concept has recently been challenged.
To further understand the mechanism of MS re-myelinization failure, we evaluated the number of less protrusive glial cells in different MS lesions types in whiteness, the presence of myelin re-formation, and the inflammatory environment, and conducted in-body experiments using less protrusive glial cells (hiOL) derived from induced omnicnicnicnic cells (iPSCs) and polarized human small glial cells.
Our results show that there are many reasons for the failure of re-myelinization of multiple sclerosis, which depends on the stage of lesions, including: although there are mature less protrusive glial cells in the subposure of active lesions, but lack of myelin formation;
: This study collected samples of paraffin-encumbased brain biopsies and autopsy tissues from 62 patients retrospectively.
the queue included 38 biopsy tissue samples from 32 patients and 113 MS lesions (81 tissue blocks) from 30 patient autopsies.
autopsy, 53 tissue blocks (71 lesions) from 17 patients were collected by the Institute of Neuropathology at The University Hospital of Mister.
From the Dutch Brain Bank, the Netherlands Institute of Neuroscience, Amsterdam, 28 tissue blocks with 42 lesions from 13 patients; all materials were collected from donors who had written informed consent for brain dissection, and NBB had obtained material and clinical information for research purposes.
biopsy is part of an unclear single lesions diagnostic assessment that shows atypical magnetic resonance imaging results.
study authors were involved in the decision-making of biopsies or autopsies.
the study was approved by the University of Minnesota and the McGill University Ethics Committee.
, we believe that successful development of myelin-promoting drugs requires better in vivo and in vitro models to simulate the pathological characteristics of different types of MS lesions.
, K., Starost, L., Kieran, N.W. et al. Lesion stage-dependent causes for impaired remyelination inMS. Acta Neuropathol 140, 359-375 (2020). MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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