Administration | Research status of anti-motion sickness sustained and controlled release drugs

Motion sickness, also known as motion sickness, refers to the dysfunction of the body's central and autonomic nervous system caused by the movement of vehicles, boats or airplanes and other means of transportation such as swings, rotations, bumps, etc.

At present, most of the common anti-motion sickness drugs on the market are in common dosage forms, such as Phencynonate Hydrochloride Tablets, with the trade name of Fycerol; Difenidol Hydrochloride Tablets, with the trade name of Vertigo; Diphenhydramine Tablets, The product name is Cheng Yuning, also known as Yun Haining.

01 Transdermal drug delivery formulations

Compared with traditional dosage forms, transdermal preparations can avoid the first pass effect, reduce the side effects related to gastrointestinal administration, can realize the slow release of the drug, prolong the onset time of the drug, and reduce the number of medications; at the same time, it can also be administered by The area is flexible to adjust the dosage, which is convenient for patients to self-administer medication and terminate medication at any time.

Among the anticholinergic drugs, scopolamine has a strong central effect.

Microemulsion can increase the solubility and fluidity of the drug, and promote transdermal absorption.

02Slow and controlled release preparations for nasal use

Temperature-sensitive in-situ gel refers to the preparation and administration in the state of a solution, the phase transition occurs due to temperature change stimulation at the medicinal site, forming a gelated semi-solid preparation, this type of preparation has good compliance and slow and controlled release Ability, and has the characteristics of high bioavailability.

03Oral sustained-release preparation

Nanoparticle-microsphere system (NiMS) is a new type of drug delivery system that uses polymer materials and encapsulation technology to wrap nanoparticles into microspheres.

Dimenhydrinate is a compound of diphenhydramine and 8-chlorophylline, and is a histamine H1 receptor antagonist.

The current effective anti-motion sickness drugs mainly include anticholinergic drugs, such as scopolamine, phencyclonate hydrochloride, etc.

Reference materials:

[1] Zeng Yuan, Zhang Yun, Wu Fen, Liu Hui.

[2] Liu Yuanyuan, Fu Wei, Zheng Aiping.