Advances have been made in the full synthesis study of the cell relaxation polypolymer series

Complex and diverse natural products are an important source of small molecular drug discovery, although natural products are rich and diverse in structure but their natural sources are limited, it is difficult to carry out in-depth research on its chemical properties and biological activities, therefore, how to obtain a simple, efficient, large number of natural products with specific structures and their similars become natural products chemical synthesis, biosynthetic and organic synthesis methods of important research content.
cell relaxin is a large group of poly ketones and amino acids mixed together, novel structure, significant activity of fungal secondary metabolites.
years, domestic plant chemists have isolated and obtained a series of complex and diverse structure, with a certain anti-tumor activity of cell relaxin-type polypolymers, attracting the attention of many synthetic chemists at home and abroad.
2018, the natural product synthesis chemistry team at the Kunming Plant Research Institute of the Chinese Academy of Sciences completed the full synthesis of the family's first cell relaxant asperchalasine A (Angewandte Chemie International Edition, 2018, 57, 14221-14224) with a key reaction of bionic phthalates.
recently, the team used Bioinspired Network Analytics, based on early work, to start with epicoccine and asponchalasin B and D fragments, with phthalates. 2. Miscellaneous polygenic reaction, light triggers the ring-plus-series enlargement ring re-scheduling reaction, and PMe3-mediated MBH type reaction, completing a series of complete synthesis of more than 10 representative cell relaxation polypolymers.
this study provides an important reference value for revealing the origin synthesis pathway of cell relaxin polypolymers and discovering new natural products and synthesis strategies, and also lays a foundation for the further study of pharmacological activity.
related research was published in Chem by Biosynthetically inspired divergent syntheses of merocytochalasans, Ph.D. students Long Xianwen and Wu Hai as co-authors and researcher Deng Jun as co-authors of the paper.
research has been supported by the National Natural Science Foundation of China, the Western Light of the Chinese Academy of Sciences, and key projects in Yunnan Province.
()