Advances in atlases of the site and composition of each cell of organs and tumors.

A team of molecular biologists, astronomers and game designers, led by Greg Hannon of the University of Cambridge, will receive a grant of 20 million pounds over the next five years to study the virtual-reality map of breast cancer interactions, cancer charity Cancer Research UK has announced.
project is just one of a series aimed at building a new generation of cell atlases that detail the site and composition of each cell in an organ and tumor.
Research UK has donated more than 16 million pounds to another team that maps similar tumors, focusing on metabolism and proteins.
the end of this year, the National Institute of Mental Health (NIMH) will announce the winners of a project to map the brains of mice in extraordinary molecular detail.
February 23-24, researchers will gather at Stanford University in California to discuss the Human Cell Atlas, an unsealed program designed to map every cell in the human body.
"It's a very hot topic," he said.
Ido Amit, who studies genomics immune systems at the Weizmann Institute of Science in Israel, says, "It's all about bits, bits, bits."
the scientific community knows this must be the next step.
" molecular biologist Hannon was both surprised and inspired when he first looked at a tumor.
Hannon and colleagues used a virtual-reality model to look at blood vessels from the outside, collect a large number of immune cells, and come up with the idea of creating an unprecedented tumor atlas.
"God help me too! "It would be amazing, " he recalls.
" Hannon's first tumor was a physical model that would include the expression of thousands of genes and dozens of proteins in each cell of a tumor.
he hopes such spatial and detailed functions will reveal more about the factors that influence a tumor's response to treatment.
past few years, researchers have been keen on techniques that allow them to measure complete CYT supplements, thousands of each cell.
these CYTs can reveal which genes are expressed and provide clues to the unique function of a cell in an organ or tumor.
but measurement methods often require cells to be removed from the tissues in which they live.
this will destroy valuable information about where cells are and what neighbors they interact with, which may contain new clues about cell function and how it is distorted in diseased tissue.
" single-cell sequencing technology has many exciting and promising areas.
," says Nicola Crosetto, a molecular biologist at the Karolinska School of Medicine in Stockholm, Sweden.
" technology is already emerging.
February 6, Amit and Shalev Itzkovitz of the Weizmann Institute and colleagues reported that they had created a small leaf map of the livers of mice made up of cells, which were done through the LDS sequence of each cell.
liver leaves in mice are usually divided into the coentric layer; the team found unique patterns of gene expression in cells located at the junction of two levels.
" is not only a transition zone, but also a new area with special features.
, Hannon is also working with Xiaowei Zhuang, a biophysicist at Harvard University in Massachusetts, who has developed a way to encode RNA with binary barcodes that can be read in cells using imaging technology.
technology allows thousands of RNAs to be tested simultaneously within a cell without losing contact with its surroundings.
"Every time I see these images with prominent QR codes, it reminds me of the movie Hacking Empire.
," Hannon said.
way to get it to the top, researchers will need to develop new channels to showcase data, Hannon said.
" virtual reality is very powerful.
," he said, "but the amount of information is going to be very large, and we're going to need new ways to deal with that information."
"