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The role of the microbiome in human health and disease has received increasing attention from the academic community.
In recent years, it has become a hotspot and key field in life sciences.
The academic community has accumulated a lot of data in the research of the human microbiome (such as the basic composition and function of the intestinal flora), but there are still problems that need to be solved urgently in the environmental and host factors that affect the microbiome.
The human genome interacts closely with genes related to metabolism and immunity as well as the microbiome, which may affect the diversity of microorganisms.
As a complex ecosystem, the microbiome is disturbed by a large number of random factors.
Therefore, the human body's genes that affect the composition of the host microorganisms are studied.
Genome-wide association studies (GWAS) are needed in large populations, and innovative analysis methods are also needed.
Recently, Nature Genetics published online the latest research results of the international large-scale research project "MiBioGen"——Large-scale association analyses identify host factors influencing human gut microbiome composition.
Wang Jun, a researcher at the Institute of Microbiology, Chinese Academy of Sciences, is the co-first author of the paper.
It is also the only participant from China.
The study included 24 cohorts from multiple countries and races in Europe, America, the Middle East, and East Asia, and data on genomes and intestinal flora of more than 18,000 people.
It is by far the largest GWAS work on intestinal flora.
The study revealed the heterogeneity of the intestinal flora among different populations, and identified high heritability bacterial groups and multiple gene loci that affect the composition of the flora; through gene set enrichment analysis, full phenotype groups Association studies and Mendelian randomization methods have explored the potential impact of genetic-microbe associations on host health-related characteristics.
MiBioGen is a large-scale international research project initiated by Wang Jun and scientists from Belgium and the Netherlands to study the impact of human genes on the intestinal flora from the level of the whole genome.
The plan has established a series of new research methods, and the above results are the first batch of research results officially published by the plan.
In addition, Wang Jun also cooperated with researchers from West Lake University and Sun Yat-sen University, and recently published the research results on Microbiome entitled The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.
The researchers selected the microbiome of 1475 Chinese for GWAS analysis to explore the influence of genetics on the intestinal flora; through two-way Mendelian randomization analysis, the causal relationship between the human intestinal flora and complex diseases was studied, and according to The commonness and characteristics of flora characteristics clustered different diseases, and found that the common flora characteristics between different diseases (such as between Parkinson's disease and colorectal cancer, between systemic lupus erythematosus and chronic myeloid leukemia) may Similar flora characteristics.
This study is the first systematic study of flora-related GWAS in the Chinese population, and is of great significance for understanding gene and flora interactions and disease occurrence in the Chinese population.
Wang Jun's research group has long been concerned about the interaction between human genes and the microbiome in health and disease, and conducted a series of in-depth studies using GWAS tools.
In 2016, after publishing a cover article in Nature Genetics, after completing the first GWAS (Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
2016, 48:1396-1406) research work, Invited to publish a review article Of genes and microbes: solving the intricacies in host genomes (2018, 9(5):446-461) on Protein Cell, systematically introducing the research methods and existing work of gene-microbes interaction; Published a review article Strengthening the functional research on the interaction between host genes and microbiota (2020, 63: 929–932) in "Science China: Life Science" (Science China: Life Science), calling for more research in the Chinese population Research and cooperation at home and abroad to jointly analyze the genetic basis of the structure and function of the human microbiome.
The research project of Wang Jun's research group was funded by the Chinese Academy of Sciences' Strategic Leading Science and Technology Special "Pathogen Host Adaptability and Immune Intervention", the key research and development project of the Ministry of Science and Technology, the National Natural Science Foundation of China's major research program cultivation project and general projects.
Figure 1.
The title of the natural genetics article and the basic information of the population collected in the project.
Figure 2.
The GWAS analysis in the Chinese population and the follow-up study of the association with the disease.
Figure 3.
Wang Jun was invited to give a review for the Protein Cell special issue.
The main picture was selected as the back cover of the current issue.
Source: Institute of Microbiology, Chinese Academy of Sciences
In recent years, it has become a hotspot and key field in life sciences.
The academic community has accumulated a lot of data in the research of the human microbiome (such as the basic composition and function of the intestinal flora), but there are still problems that need to be solved urgently in the environmental and host factors that affect the microbiome.
The human genome interacts closely with genes related to metabolism and immunity as well as the microbiome, which may affect the diversity of microorganisms.
As a complex ecosystem, the microbiome is disturbed by a large number of random factors.
Therefore, the human body's genes that affect the composition of the host microorganisms are studied.
Genome-wide association studies (GWAS) are needed in large populations, and innovative analysis methods are also needed.
Recently, Nature Genetics published online the latest research results of the international large-scale research project "MiBioGen"——Large-scale association analyses identify host factors influencing human gut microbiome composition.
Wang Jun, a researcher at the Institute of Microbiology, Chinese Academy of Sciences, is the co-first author of the paper.
It is also the only participant from China.
The study included 24 cohorts from multiple countries and races in Europe, America, the Middle East, and East Asia, and data on genomes and intestinal flora of more than 18,000 people.
It is by far the largest GWAS work on intestinal flora.
The study revealed the heterogeneity of the intestinal flora among different populations, and identified high heritability bacterial groups and multiple gene loci that affect the composition of the flora; through gene set enrichment analysis, full phenotype groups Association studies and Mendelian randomization methods have explored the potential impact of genetic-microbe associations on host health-related characteristics.
MiBioGen is a large-scale international research project initiated by Wang Jun and scientists from Belgium and the Netherlands to study the impact of human genes on the intestinal flora from the level of the whole genome.
The plan has established a series of new research methods, and the above results are the first batch of research results officially published by the plan.
In addition, Wang Jun also cooperated with researchers from West Lake University and Sun Yat-sen University, and recently published the research results on Microbiome entitled The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.
The researchers selected the microbiome of 1475 Chinese for GWAS analysis to explore the influence of genetics on the intestinal flora; through two-way Mendelian randomization analysis, the causal relationship between the human intestinal flora and complex diseases was studied, and according to The commonness and characteristics of flora characteristics clustered different diseases, and found that the common flora characteristics between different diseases (such as between Parkinson's disease and colorectal cancer, between systemic lupus erythematosus and chronic myeloid leukemia) may Similar flora characteristics.
This study is the first systematic study of flora-related GWAS in the Chinese population, and is of great significance for understanding gene and flora interactions and disease occurrence in the Chinese population.
Wang Jun's research group has long been concerned about the interaction between human genes and the microbiome in health and disease, and conducted a series of in-depth studies using GWAS tools.
In 2016, after publishing a cover article in Nature Genetics, after completing the first GWAS (Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
2016, 48:1396-1406) research work, Invited to publish a review article Of genes and microbes: solving the intricacies in host genomes (2018, 9(5):446-461) on Protein Cell, systematically introducing the research methods and existing work of gene-microbes interaction; Published a review article Strengthening the functional research on the interaction between host genes and microbiota (2020, 63: 929–932) in "Science China: Life Science" (Science China: Life Science), calling for more research in the Chinese population Research and cooperation at home and abroad to jointly analyze the genetic basis of the structure and function of the human microbiome.
The research project of Wang Jun's research group was funded by the Chinese Academy of Sciences' Strategic Leading Science and Technology Special "Pathogen Host Adaptability and Immune Intervention", the key research and development project of the Ministry of Science and Technology, the National Natural Science Foundation of China's major research program cultivation project and general projects.
Figure 1.
The title of the natural genetics article and the basic information of the population collected in the project.
Figure 2.
The GWAS analysis in the Chinese population and the follow-up study of the association with the disease.
Figure 3.
Wang Jun was invited to give a review for the Protein Cell special issue.
The main picture was selected as the back cover of the current issue.
Source: Institute of Microbiology, Chinese Academy of Sciences
