Advances in tool research that reveal a variety of gut bacteria.

Gut bacteria have a wide range of effects on human health, but there is no tool to explore the relationship between microbial activity and host physiological function.
, two independent research groups published a paper in the journal Cell that they have overcome this barrier and developed new tools that can reveal multiple gut bacteria at the same time.
method could help researchers find out where bacteria are in the gut based on the different colors they emit.
found that synthetic biology tools allow us to ask new questions about gut bacteria, " he said.
a senior author of one of the papers, Andrew Goodman of Yale University School of Medicine, said the strategy could help develop new treatments.
one study, Justin Sonnenburg of Stanford University School of Medicine and colleagues developed a way to revamp Bacillus to track multiple strains in the gut at the same time.
these tools include a synthetic activated sub-DNA sequence panel that can begin copying specific genes.
the panel, the researchers genetically modified different anthropobacteria to create a unique combination of mCherry and green fluorescent protein (GFP).
they implanted the combination in sterile mice, and two weeks later, a fluorescent microscope was used to analyze colon slices in mice to find out where the bacteria were located in different parts of the intestine.
other study, goodman's team also developed a synthetic activation sub-panel that fine-tunes the genetic activity of different Bacillus.
scientists integrated these activaters into the mycobacteria gene and adjusted their genetic activity using a tyrocycline regulatory system so that the turning on or off of gene transcription depended on the presence or failure of waterless cyclin.
, in a missing state, gene activity controlled by synthetic activated sub-control is also completely shut down, but when aurasin is present, genetic activity increases rapidly.
, the researchers moved the modified bacteria into mice, confirming the theory.
tools open up a better understanding of human microbes and define how gut symbiotic bacteria should be modified for treatment.
," Sonnenburg said, but more research is needed before it can be used for treatment.
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