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After infection with the new crown, the patient's antibody declines, but the T cell immune protection continues

 Last Update: 2021-08-13
 Source: Internet
 Author: User

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After infection with the new crown, the patient's antibody declines, but the T cell immune protection continues

Contribute to the development of new coronary pneumonia vaccines

Decline in patient antibody after infection new crown, but decreased T-cell immunity in patients with antibodies to protect the new crown after persistent infection, T-cell immune protection but continued tocontribute to the development of new crown pneumonia vaccine helps to crown a new pneumonia vaccine R & D help crown the new pneumonia vaccine development

Recently, the research team of Professor Lu Hongzhou and Associate Professor Chen Jun of the Shanghai Public Health Clinical Center has shown the protective effect of neutralizing antibody levels and new coronavirus-specific T lymphocyte responses over time in 27 recovered patients 7 months after infection.
After conducting the study, it was found that the neutralizing antibody immune response of the patient decreased, but the T lymphocyte immunity continued
.

This result is very important for understanding the innate immune response and will help the development of a new coronary pneumonia vaccine

According to Lu Hongzhou, T lymphocytes are divided into two categories: CD8 ⁺ and CD4 ⁺
.

The former can recognize the cells infected by the virus and kill the virus.

⁺⁺⁺

A study by Lu Hongzhou’s team found that 96.
3% of patients can still detect protective neutralizing antibodies at their second visit about 7 months after the onset of symptoms.
However, their humoral response includes the spike receptor binding domain in the body.
The titers of antibodies and neutralizing antibodies were significantly reduced compared with the first visit
.

In contrast, the proportion of CD4 ⁺ T cells specific to the new coronavirus in patients with recovered new coronary pneumonia continued to be higher than that of the healthy control group, but the proportion of CD8 ⁺ T cells did not change so significantly

⁺⁺⁺

Researchers have concluded through research that the new coronavirus-specific T cell immune response persists, while neutralizing antibodies decline
.

This requires further research to extend the life of neutralizing antibodies and assess whether these T cells are sufficient to protect patients from reinfection

Lu Hongzhou said that the study is also conducting joint inspections of neutralizing antibodies, CD4 ⁺ T cells, and CD8 ⁺ T cells in the same patient population for the response to the new coronavirus
.

This is very important for understanding the innate immune response and helps the development of new coronary pneumonia vaccines

⁺⁺