After the rare disease, he discovered a secret of the new crown pneumonia

Every morning, DrDavid Faigenbaum, a doctor, David Fajgenbaum) takes three life-saving pills and drinks some yogurt quickly before starting workFor the next 14 hours, he spent most of the time reviewing and analyzing all the drugsso far used to treatnew coronary pneumonia with researchers and volunteersHis team has studied more than 8,000 papers on the treatment of neo-coronary pneumoniaFaigenbaum works at the CytokinStorm Treatment and Laboratory Center at the University of Pennsylvania's Perelman School of MedicineFor the past few years, he has been working on castleman disease, a disease that nearly killed his lifesix years ago, he found a life-saving drug, siromos, animmuno
inhibitor used in kidney transplant patientsThe drug prevents the body from producing cytokine storms (the bodyinfected withvirus, the immune system overreacts, causing attacks on the virus while also attacking its own cells)Cytokine storms are responsible for severe lung damage, organ failure, clotting disorders, or pneumonia in patients with new coronary pneumoniaAfter discovering that patients with new coronary pneumonia had cytokine storms similar to Castleman's disease, Faigenbaum's lab began to devote all its energy to the treatment of new coronary pneumonia " I survived because of Siromos He said now, the re-use of old drugs to treat the new crown pneumonia has become a global priority a global database of new coronary pneumonia therapy
Faigenbaum and colleagues have reviewed and analyzed public data on more than 150 drugs for the treatment of new coronary pneumonia They published the results in a database named CORONA The database contains all the data on the treatment of neo-coronary pneumonia that have appeared so far in scientific journals The database not only assists doctors in treatment, but also guides researchers through clinical trials based on the database, The Faigenbaum team published the first systematic review of the treatment for new coronapneumonia in the journal Infectious Diseases and Treatment in May In this review, they analyzed 2,706 published papers, but ultimately they didn't find a drug that worked for all patients Because each patient's timing, severity of the disease, and the stage of disease development vary widely, a single change in these variables can ineffectiveize an otherwise effective drug, making it difficult to study only one therapy However, as the number of patients in the database increases, these clinical data also show some noteworthy information patients with new coronary pneumonia with severe cytokine storms are more likely to target immunosuppressants, while patients with severe cytokine storms may need immunoenhanceants In addition, there are antiviral drugs that can be used to treat neo-coronary pneumonia, some of which can prevent viral infections in cells, and others that can delay the replication of the virus within cells The establishment of the CORONA database itself did not find a "magic cure" and instead helped researchers design better clinical trials to find a real causal relationship between drugs and patient survival Faigenbaum hopes that in the battle against the new coronavirus, the CORONA database will illuminate the way forward, so that doctors can accurately pound their lives "It's very difficult to win this battle if you don't know the weapons used by the enemy," he said and FDA analysts
faigenbaum's team built a CORONA database similar to what the FDA is doing in the United States Over the years, the FDA has been developing an application called CURE ID Launched in December 2019, the app has two aims: to help doctors explore new treatment ideas, prescription guidelines and emergency medication advice for hundreds of diseases, and to allow doctors around the world to share information to quickly see if there are new success stories of older drugs the Faigenbaum team worked with FDA analysts Both sides have made up for shortcomings between government departments and private institutions " outbreak of new crown pneumonia also illustrates our failure to develop a vaccine Amitabh Chandra, a health economist who teaches at Harvard Kennedy School and Harvard Business School, said, "Before the outbreak of new crown pneumonia, we didn't have the right incentives for vaccine production "
no old vaccine can be used to fight the new coronavirus, but there are hundreds of drugs in pharmacies that can be used to save lives, including some of the old drugs that can be used to treat the new coronapneumonia Faigenbaum's team found that the antiviral drugs lopinavir and Litonevir have been the most studied to date for the treatment of new coronapneumonia In addition, corticosteroid drugs also show their unique prospects A recent study of the steroid drug dexamethasone in the UK showed that a 10-day low-dose desemethycanon reduced the risk of death by a third in hospital patients who needed assisted breathing data on dexamethasone is like a beacon that illuminates the path to the treatment of the new crown pneumonia "Dexamethasone is a cheap drug that has been on the market for 60 years, and we created the CORONA database to find drugs like dexamethasone." Faygenbaum said repeated life-saving methods
Every attack in Kasman's disease triggers cytokine storms that lead to multiple organ failure Faigenbaum, who suffers from the disease, has been on the brink of death five times, but the young doctor brought together doctors, scientists and patients to create a global organization to find a cure for the disease With the help of extensive research and excellent partners, an immunosuppressant was eventually discovered that saved his life although he still needs chest infusions, Faigenbaum had not been exposed to cytokine storms for 77.72 months as of June 27 The last time the disease returned was on January 5, 2014 Every day is a precious moment for Faigenbaum, who is always worried that he will never see his daughter again ", "Every time I touch the infusion port, I think of the cytokine storm I've been through He said, "I really want to save patients with new crown pneumonia in the same way that They treat Castleman's disease." 2019, he published his memoir, "Retroactive My Treatment," detailing the treatment of Castle's chronic disease The book chronicles a priest who went to the ward to give him the final farewell ceremony of his life His story reads like a series, and all of this is only the first season now, the CORONA database will move the story to the next step Faigenbaum has used his experience with Castleman's disease in the battle against new crown pneumonia Xu Weiwei (compiled) Source: health