echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > Age & Aging: Don't underestimate weakness, it can lead to diabetes, coronary heart disease, and even stroke!

    Age & Aging: Don't underestimate weakness, it can lead to diabetes, coronary heart disease, and even stroke!

    • Last Update: 2023-01-04
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    In observational studies, weakness has been strongly associated
    with cardiometabolic diseases.
    However, whether the observed association reflects causation needs to be clarified
    .
    To this end, Chinese scholars from Hangzhou Medical College conducted a two-way Mendelian randomization (MR) study to evaluate the causal relationship
    between frailty, as measured by the frailty index (FI), and coronary artery disease (CAD), stroke, and type 2 diabetes (T2D).

    The researchers extracted genome-wide statistical abstracts
    of FI (N = 175226), CAD (Ncase = 60801, Ncontrol = 123504), stroke (Ncase = 40585, Ncontrol = 406111), and T2D (Ncase = 55005, Ncontrol = 400308) in individuals of European ancestry.
    Independent genetic variants associated with each phenotype at the genome-wide significance level are used as tools
    .
    Two-sample MR analysis was mainly performed using the antivariance weighting method, followed by various sensitivity and confirmatory analyses
    .

    The results showed that higher FI predicted by posthumous prediction was significantly associated with increased risk of CAD (OR=1.
    52, 95% confidence interval [CI]1.
    17-1.
    96) and T2D (OR=1.
    80, 95% CI 1.
    31-2.
    47), and implied a higher risk of stroke (OR=1.
    36, 95% CI 1.
    01-1.
    84).

    。 In the reverse analysis, genetic responsibility for CAD (β 0.
    037, 95% CI 0.
    019-0.
    055), stroke (β 0.
    096, 95% CI 0.
    051-0.
    141) and T2D (β 0.
    047, 95% CI 0.
    036-0.
    059) was clearly associated
    with increased FI.
    The results were stable
    in both sensitivity and confirmatory analyses.

    Taken together, the study strengthens the evidence for a bidirectional causal relationship between frailty and cardiometabolic disease.

    Further understanding of this association is critical
    to optimizing care for older adults.

     

    References:

    Frailty and cardiometabolic diseases: a bidirectional Mendelian randomisation study, Age and Ageing, Volume 51, Issue 11, November 2022, afac256, https://doi.
    org/10.
    1093/ageing/afac256

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.