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Aging Cell: Tumor suppressor miR-34c as a new target for AD therapy

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Epidemiological studies have shown that there is a negative correlation between Alzheimer's disease (AD) and cancer.

1miR-34c is regulated by ROC-JNK-p53 and is associated with AD pathology

The present study firstly determined the increased expression level of miR-34c in vivo (SAMP8 mouse model-aging accelerated model) and in vitro (H2O2-stimulated oxidative stress neurons and Aβ42-stimulated AD cell model)

2miR-34c targets SYT1

The target genes of miR-34c were predicted by bioinformatics analysis and validated

3 Serum miR-34c levels increased in patients with mild cognitive impairment (aMCI)

aMCI is a transitional stage between normal aging and dementia and represents an early stage of AD

Figure.

AD is an aging-related disease.

Compilation Author: Peter Pan (Brainnews creative team)

Reviewer: Victoria, Simon (Brainnews editorial office)

references:

Shi Z, Zhang K, Zhou H, et al.

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