Aging: Diluted blood can return to old age

Studies have shown that blood sharing from young individuals can make tissue younger in aging individuals, and most of the research on such work has focused on young plasma, its composition, and some young systemic candidatesHowever, the researchers have not formally identified young blood as a necessary condition for this multi-tissue youthrecently, researchers used their recently developed small animal blood-for-blood model to replace half of the plasma in mice with 5% albumin in physiological saline (called 'neutral' age blood exchange, NBE), thereby diluting the plasma factor and supplementing albumin, which decreased if only physiological saline was usedData fromresearchers show editing that a single NBE is sufficient to enhance muscle repair, reduce liver fat and fibrosis, and increase the younger effect of hippocampus neurogenesis in older mice, all key results seen after previous blood exchangesFor a comparative analysis of serums from NBE, as well as similar human clinical procedure therapeutic plasma exchange (TPE), the researchers found that the molecules of the system's signaling environment were resetInterestingly, it raises levels of proteins that broadly coordinate tissue maintenance and repair, and promoteimmuneresponseand, at one time, TPE can produce functional blood regeneration, eliminating the typical senescent serum inhibits proliferator cell proliferationThe added albumin does not appear to be the only factor determining this youth, and albumin levels do not decrease with age or increase with NBE/TPEa model of action (supported by a large amount of published data) is that by altering gene expression, the self-discipline protein sintted in series with multiple signaling pathways (with its own feedback loop) will produce lasting molecular and functional effects consistent with the experimental observationsin general, this work has improved our understanding of the systemic paradigm of multi-tissue youth and proposed a novel way to improve the health and resilience of older people withFDAapproved TPEs