Aging: Mitochondrial peptide humanin regulates life and health

Humanin is a member of a new family of peptides encoded within the mitochondrial genome by a short open reading boxIt is conservative in animals and has neuroprotective and cellular protectionrecently, researchers found that overexpression of humanin in beautiful nematodes is enough to increase life expectancy, which relies on the daf-16/Foxo signaling pathwayHumanin genetically modified mice have many episotypes, similar to worm sohelIn addition, humangenetically modified mice can increase protection against toxin interference, similar to exogenous humanin treatmentstreating middle-aged mice twice a week with the powerful humanin analogue HNG can improve metabolic health parameters and reduce inflammatory markersin multiple species, humanin levels usually decline with age, but here the researchers show that humanin levels are surprisingly stable in naked mole ratsin addition, centenarians' children are more likely to be centenarians, with higher levels of humanin in their blood circulation than age-matching controlsfurther linking humanin to healthy life, the researchers observed that humanin levels decreased in human diseases such as Alzheimer's disease and MELAS (mitochondrial encephalopathy, lactic acidosis, andstroke-like seizures)these studies have shown that humanin is associated with improved health and longer life expectancy