AIE probe realizes high-efficiency tumor photodynamic-immune synergistic therapy

Schematic diagram of synthesis of aggregation-induced luminescence biomimetic probe M@AP

In an article recently published in the National Science Review (National Science Review, NSR), researchers used red blood cell membrane load aggregation induced luminescence (AIE) photosensitizer and immune adjuvant Poly(I:C) in a mouse model Realize the high-efficiency photodynamic-immune synergistic therapy for tumors.

The principle of photodynamics therapy (Photodynamics therapy, PDT) is: after the photosensitizer is introduced into the tumor, under the action of light, the photosensitizer will induce the tumor cells to produce excessive reactive oxygen species to kill the tumor cells; at the same time, PDT can also promote tumor-related The antigen is released, thereby initiating the body's anti-tumor immunity.

Poly(I:C) is a Toll-like receptor 3 agonist, which can directly induce tumor cell apoptosis and promote the secretion of immune factors by tumor cells.

In vivo experiments show that the M@AP probe can not only kill tumor cells directly under light, but also activate immune cells under the synergistic effect of Poly(I:C), and promote the cytokine interleukin 1 (IL1) and interleukin 1 (IL1).

Related paper information: org/10.