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Aims to functionally cure hepatitis B RNAi immune combination therapy to carry out phase 2 clinical trials

 Last Update: 2022-01-11
 Source: Internet
 Author: User

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On December 9, 2021, Vir Biotechnology announced that a phase 2 clinical trial of a novel combination of RNAi therapy VIR-2218 has completed the first patient administration for the treatment of patients with chronic hepatitis B virus (HBV) infection

VIR-2218 is a subcutaneously administered siRNA targeting the X gene of HBV jointly developed by Vir and Alnylam Pharmaceuticals.

▲Introduction to VIR-2218 (picture source: reference [2])

This multi-center, open-label Phase 2 clinical trial aims to evaluate the safety, tolerability and efficacy of various therapeutic combinations of VIR-2218 in combination with selgantolimod, nivolumab and TAF in the treatment of adult patients with chronic HBV infection

Reference materials:

[1] Vir Biotechnology Announces Initiation of Phase 2 Clinical Trial Evaluating VIR-2218, Selgantolimod and Nivolumab for the Treatment of Chronic Hepatitis B Virus Infection.

[2] Safety and Antiviral Activity of VIR-2218, An X-Targeting RNAi Therapeutic, In Participants With Chronic Hepatitis B Infection: Week 48 Follow-Up Results.

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