AJP: discovery of new protein can prevent the growth of colon cancer and prolong the survival of patients

July 18, 2018 / Biovalley / researchers from Boston University School of Medicine (BUSM) found a new target protein, c-cb1, which they believe will help to further understand colon cancer and ultimately improve the survival rate of patients They found that colon cancer patients with high levels of c-cb1 have a longer life span Although scientists have studied the protein in other cancers, no one has studied the role of the protein in colon cancer The researchers measured the level of c-cb1 in the tumor tissue removed from patients with colon cancer Based on the content of this protein, patients were divided into two groups, high-level group and low-level group The researchers then wondered what happens to the cells when the protein is turned off Therefore, they divided two kinds of colon cancer cells into three groups: one is normal colon cancer cells, one is normal c-cb1 expression enhanced cells, the other is closed c-cb1 expression enhanced cells, the closed c-cb1 lacks the function of normal c-cb1 ubiquitin ligase The results showed that the cells in the third group grew faster than those in the second group Tumor growth and metastasis need neovascularization So the researchers next explored how c-cb1 affects vascular growth in these three groups of cells The results showed that the third group of cancer cells would grow more blood vessels "This helps us understand the role of c-cb1 ubiquitin ligase in its ability to prevent tumor growth and reduce tumor angiogenesis." Vipul chitalia, Ph.D., associate director of BUSM, the study's co-author, said The researchers say the study suggests that c-cb1 may improve survival in patients with colon cancer "This information will help cancer researchers learn more about colon cancer, and may help them design better new ways to treat colon cancer, and make patients live longer." The study was published in the American Journal of philosophy Reference: new target protein for colon cancer identified