Alz Res Therapy: Fudan University-Shanghai Research on Aging, renal dysfunction is closely related to dementia

In the current aging society, nearly 50 million people worldwide suffer from dementia, and this number is expected to increase to 131 million by 2050
.

Globally, the burden of dementia on society is only partially reflected in the estimated annual cost of US$ 818 billion, which has exceeded the cost of any other disease

Decline in renal function may be part of the aging process, because it is the heart blood vessel disease, weakness and other adverse health events, and therefore have an increasingly important public health implications
.

In addition, decreased renal function may lead to vascular damage and metabolic abnormalities, which may lead to a high possibility of dementia

Heart blood vessels

Some large population-based studies have investigated the relationship between renal dysfunction and the incidence of dementia, but the reported results are not consistent
.

The main heterogeneity of these studies is the different measures of renal function, namely the reciprocal of serum creatinine (1/SCr), estimated glomerular filtration rate (GFR) based on creatinine (GFRcr) or cystatin-C (GFRcys)

diagnosis

The Shanghai Aging Study collected baseline serum samples for cystatin C and creatinine measurements, and also conducted comprehensive clinical interviews on the cognitive function of the community cohort
.

In this study, Mengjing Wang and others of Fudan University verified that lower levels of kidney function increase the risk of dementia in the elderly in China

diabetes

Result
.

A total of 113 (8%) and 84 (7%) participants suffered from dementia and AD

(HRs) were 1.
87 (95% CI 1.
02-3.
44) and 2.
19 (95% CI 1.
21-3.
95), respectively
.

Compared with high GFRcrcys, low (HR=2.
27[95%CI 1.
10-4.
68]) and medium (HR=2.
14[95%CI 1.
04-4.
40]) baseline GFR-crcys were also independently associated with the occurrence of AD after adjustment
.

A significant association between GFR-crcys and dementia risk was observed in female participants, but not in male participants
.

The important significance of this research lies in the discovery: GFR-crcys can be considered as a sign of the risk of personal cognitive decline
.

GFR-crcys can be considered as a sign of the risk of personal cognitive decline
.

 

Original source: Wang M, Ding D, Zhao Q, et al.

Kidney function and dementia risk in community-dwelling older adults: the Shanghai Aging Study.

 

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