Alzheimer Dementia-Lymphatic system, indeed helps clear amyloid from the brain

Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) are important causes of cognitive and movement disorders in the elderly
.

Since these functions are in the brain, the investigation of these diseases mainly focuses on the pathological changes of brain tissue, and great progress has been made in understanding the pathogenesis

The brain features of AD are senile plaques and neurofibrillary tangles (NFT), as well as the pathological expression of abnormal metabolism of two proteins: amyloid β (Aβ) and tau protein
.

There is evidence that these proteins interact in various oligomeric states or misfolded conformations and induce reactive microglia responses that ultimately lead to synapses and neuronal degeneration

But BBB may not be the only way for Aβ and other proteins to leave the central nervous system, but BBB may not be the only way for Aβ and other proteins to leave the central nervous system

In recent years, people have increasingly realized that the hepatitis B system is a way to remove solutes and proteins from the brain
.

The system is anetwork of perivascular pathways that allow the exchange of interstitial fluid (ISF) and CSF and the excretion of soluble proteins and metabolites (including Aβ) from the brain parenchyma

immunity

There are Aβ-labeled cells in the lymph nodes, and the abundance of labeled cells displayed in the cervical lymph nodes is much higher than that in the inguinal lymph nodes
.

This observation supports the hypothesis that the lymphatic system helps clear Aβ from the human brain

There are Aβ-labeled cells in the lymph nodes, and the abundance of labeled cells displayed in the cervical lymph nodes is much higher than that in the inguinal lymph nodes

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