Alzheimer's: Amyloid and tau are a dangerous combination

"It has long been known that tau deposition in the so-called hippocampus and adjacent brain regions impairs memory

Data collection at multiple sites

The data currently evaluated come from a long-term study (DELCODE) conducted by DZNE in cooperation with university hospitals, in which 10 research centers in Germany participated

Levels of amyloid and tau proteins in the cerebrospinal fluid are commonly used indicators to assess the burden of these proteins on the brain

Support anti-amyloid therapy

"Our data show several relevant associations

This is the anti-amyloid therapy using "monoclonal antibodies", which is currently undergoing clinical trials, of which "Aducanumab" (brand name: Aduhelm) is the first drug approved in the United States

Journal Reference :

1. Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen.