Alzheimer's Dementia: Almost all elderly people have brain lesions-these lesions indicate the risk of dementia in the future!

Characteristics of age-related dementia is the misfolding and aggregation of proteins inside and outside the cells are deposited or cerebral vascular disease (CVLS)
.

Currently, post-mortem neuropathological evaluation of brain tissue isthe only definitive method for diagnosis and classification of diseases

Characteristics of age-related dementia is the misfolding and aggregation of proteins inside and outside the cells are deposited or cerebral vascular disease (CVLS)

In addition, cerebrovascular disease (CVD) and CVL may be associated with neuropathology of neurological diseases
.

However, these landmark lesions are not mutually exclusive.

In addition, cerebrovascular disease (CVD) and CVL may be associated with neuropathology of neurological diseases

Data from a large autopsy study showed that additional LowP and mixed SevP appeared together in up to 74% of the brains of elderly people, and showed that the presence of additional pathology (whether additional LowP or mixed SevP) is related to the risk of dementia or accelerated cognitive impairment
.

Data from a large autopsy study showed that additional LowP and mixed SevP appeared together in up to 74% of the brains of elderly people, and showed that the presence of additional pathology (whether additional LowP or mixed SevP) is related to the risk of dementia or accelerated cognitive impairment
.

Data from a large autopsy study showed that additional LowP and mixed SevP appeared together in up to 74% of the brains of elderly people, and showed that the presence of additional pathology (whether additional LowP or mixed SevP) is related to the risk of dementia or accelerated cognitive impairment

Another example of the clinical impact of frequently-occurring brain diseases is the accumulation of TDP-43 protein in the limbic system of the brain.
This condition has recently been called age-related TDP-43 neuropathic changes in encephalopathy (LATE-NC)
.

LATE-NC is considered a unique disease (namely LATE17)

Another example of the clinical impact of frequently-occurring brain diseases is the accumulation of TDP-43 protein mainly in the limbic system of the brain.

The prevalence and number of extra LowP increase with age
.

The prevalence and number of extra LowP increase with age
.

The data comes from 670 cases of the Alzheimer's Research Project
.

Cases were classified as PurP, mixed SevP or major disease and additional LowP; 508 participants were rated for clinical dementia

The results showed that among all participants, 69.
9% of cases had LowP, 22.
7% had PurP, and 7.
5% had mixed SevP
.

The additional LowP increased the likelihood of suffering from mild dementia and mild cognitive impairment (MCI) by nearly 20 times (odds ratio = 19.

The results showed that among all participants, 69.
9% of cases had LowP, 22.
7% had PurP, and 7.
5% had mixed SevP
.
The additional LowP increased the likelihood of suffering from mild dementia and mild cognitive impairment (MCI) by nearly 20 times (odds ratio = 19.
5)
.
The results showed that among all participants, 69.
9% of cases had LowP, 22.
7% had PurP, and 7.
5% had mixed SevP
.
The additional LowP increased the likelihood of suffering from mild dementia and mild cognitive impairment (MCI) by nearly 20 times (odds ratio = 19.
5)
.

The chord diagram illustrates the complex connections and overlaps between the main neuropathological diagnosis and the additional low-grade pathology
.

The chord diagram illustrates the complex connections and overlaps between the main neuropathological diagnosis and the additional low-grade pathology
.

It can be seen that most elderly people have a variety of brain diseases
.
The presence of additional LowP can greatly worsen the decline in cognitive ability, increasing the risk of turning from MCI to dementia by 20 times
.

It can be seen that most elderly people have a variety of brain diseases
.
The presence of additional LowP can greatly worsen the decline in cognitive ability, increasing the risk of turning from MCI to dementia by 20 times
.
It can be seen that most elderly people have a variety of brain diseases
.
The presence of additional LowP can greatly worsen the decline in cognitive ability, increasing the risk of turning from MCI to dementia by 20 times
.

 

references:

Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia.
https://doi.
org/10.
1002/alz.
12291

Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia.
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