Alzheimers & Dementia: Controlling pressure in middle-aged people to prevent dementia-middle-aged vascular risk factors and the risk of occasional dementia

Dementia is a major public health problem that places a heavy burden on patients, caregivers and the national healthcare system
.

The pathophysiological process leading to dementia begins before the patient develops clinically identifiable cognitive deficits in his later years

Dementia is a major public health problem that places a heavy burden on patients, caregivers and the national healthcare system

Several cohort studies have explored the relationship between LS7 scores and the risk of Alzheimer’s or cognitive decline, but the results are not consistent

Mendelian randomization (MR) uses gene variants associated with exposure of interest as a tool and investigates their relationship with disease outcomes, thereby overcoming some of the key limitations of observational research, such as confusion and reverse causes

Recently, researchers have used the large-scale LS7 data of 230,000 individuals between the ages of 40 and 69 from the UK Biobank (UKB) to track for 12 years: (1) Determine the baseline, that is, the score and its The relationship between biological and life>

In 229,976 people (with an average follow-up of 9 years), the researchers explored whether middle-aged cardiovascular health measured by the LS7 scale is related to sudden all-cause dementia, and whether the various components of the score are causally related to dementia
.

In 229,976 people (with an average follow-up of 9 years), the researchers explored whether middle-aged cardiovascular health measured by the LS7 scale is related to sudden all-cause dementia, and whether the various components of the score are causally related to dementia
.

 

• Adherence to the biological indicators of LS7 (blood pressure, cholesterol, blood sugar levels) is associated with a lower risk of dementia (hazard ratio=0.
  93 for every 1 point increase, 95% confidence interval [CI; 0.
  89-0.
  96])
  .
  
• In contrast, the LS7 composite score was not associated with life>
  .
  
• In a Mendelian randomized analysis, genetic hypertension was associated with an increased risk of dementia (odds ratio = 1.
  31 per standard deviation increase, 95% CI [1.
  05-1.
  60])
  .
  

Adherence to the biological indicators of LS7 (blood pressure, cholesterol, blood sugar levels) is associated with a lower risk of dementia (hazard ratio=0.
93 for every 1 point increase, 95% confidence interval [CI; 0.
89-0.
96])
.

Adherence to the biological indicators of LS7 (blood pressure, cholesterol, blood sugar levels) is associated with a lower risk of dementia (hazard ratio=0.
93 for every 1 point increase, 95% confidence interval [CI; 0.
89-0.
96])
.

In contrast, the LS7 composite score was not associated with life>

 These findings underscore the importance of controlling blood pressure in middle age to reduce the risk of dementia

Literature source: https://doi.
80599.
net/10.
1002/alz.
12320 https://doi.
80599.
net/10.
1002/alz.
12320 Leave a message here