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Accelerated long-term forgetting has been found in preclinical Alzheimer's disease (AD), which is attributed to the selective impairment of memory consolidation, in which the hippocampus plays a key role.
The study analyzed data from 39 asymptomatic participants (18 ADAD mutation carriers and 21 non-carriers) from the Chinese Familial Alzheimer's Disease Network (CFAN) study.
thrombus
Although performance was normal on the standard 30-minute delay test, mutation carriers showed accelerated forgetting of verbal and visual materials within 7 days compared to matched non-carriers.
The ROC curve is used to identify the long-term forgetting rate of preclinical mutation carriers and non-carriers.
The ROC curve is used to identify the long-term forgetting rate of preclinical mutation carriers and non-carriers.
Scatter plot with close estimates of the long-term forgetting rate of mutation carriers
Scatter plot with close estimates of the long-term forgetting rate of mutation carriersThis study provides more evidence for the existing literature describing accelerated long-term forgetting as a subclinical cognitive impairment in ADAD mutation carriers.
In summary, the study shows that accelerated long-term forgetting, as a hippocampus-dependent memory impairment, appears in the early stages of AD .
Accelerated long-term forgetting is a hippocampus-dependent memory impairment.
biomedcentral.
biomedcentral.
com/articles/10.
1186/s13195-021-00845-0#citeas" target="_blank" rel="noopener">Yang, J.
, Kong, C.
, Jia, L.
et al.
Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer's disease.
Alz Res Therapy 13, 107 ( 2021).
https://doi.
org/10.
1186/s13195-021-00845-0 Yang, J.
, Kong, C.
, Jia, L.
et al.
Alz Res Therapy 13,
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