Alzheimer's: This gene drives the brain's amyloid plaques for the first time.

In this case, it is difficult to save dead neurons by using drugs to remove amyloid deposits or nerve fiber sageThis is one of the reasons why the medical treatment of Alzheimer's has not worked well since it was discovered in 1907Researchers have been looking for "the culprits" of excessive accumulation of amyloid protein in the brains of Alzheimer's patientsPET scans of the brains of people with Alzheimer's disease Recently, a study led by researchers at Columbia University's Irvine Medical Center in the United States identified the first gene that drives the brain's amyloid plaquesThe findings could lead to new treatments to prevent Alzheimer's disease and better ways to identify people at the greatest risk of developing the diseaseThe findings were published June 22 in the journal JAMA Neurologydoi: 10.1001/jamaneurol.2020.1760 Specifically, in order to find the genes that drive the accumulation of early amyloid proteins, the latest study examined the genomes of 4,300 people whose PET images showed amyloid deposits in the brain, but have not yet developed Alzheimer's diseaseDr Richard Mayeux, professor of neurology at Columbia University's Waglos School of Medicine and The College of Surgeons who led the study, said: "By studying people with early-stage Alzheimer's disease, we can identify genes associated with the onset of the diseaseThese genes may lead to therapies that prevent the development of diseaseA genetic analysis of the RBFOX1 and APOE variants linked to amyloid protein levels in people at risk of Alzheimer's disease has found a link between amyloid protein deposits and APOE and a new gene, RBFOX1About 10 percent of the study subjects (mainly European descent) had RBFOX1 mutations associated with the appearance of amyloid protein depositsRBFOX1 appears to increase the concentration of the protein fragments that make up these plaques and may cause key connections between neurons to breakExactly revealing how RBFOX1 regulates amyloid plaques may lead to ways to prevent plaque build-upPrevious studies have shown that RBFOX1 is involved in the formation of amyloid precursors and the destruction of synapses between neuronsThe connection between RBFOX1 and amyloid plaques may be relatively easy to untangleThis is different from the connection between APOE4 and amyloid proteins, and decades of research remain unexplained"I think we're going to find that these signs of the final disease can really fight Alzheimer's disease," Mayeux said It is almost impossible to change the course of the disease when the symptoms of Alzheimer's are present Because by then the disease had developed for 10 to 15 years If we can target genes that activate amyloid and correct these problems in some way, we may be able to prevent the disease References: 1 Alzheimer's: New May Gene Drive HeritageBrain Changes.