Alzheimer's vaccine? It could be another ten years.

Science and Technology Daily reportertraced found that the main protagonist of the news, New Mexico State University (UNM), developed a model of prefrontal lobe dementia (FTD) animal model rTg4510, which can reduce the pathology of pure Tau protein aggregation, rather than an animal model of Alzheimer's diseaseAlthough the vaccine could reduce Tau load and improve cognitive ability in laboratory mice, researchers acknowledge that it could take at least a decade to develop a successful Alzheimer's vaccine in humanswhat kind of "difficult disease" is Alzheimer's disease? Why is vaccine stoin so difficult to develop?the complex pathogenesis"Alzheimer's disease" is like an eraser in the mindIt is commonly known as Alzheimer's disease, is a degenerative disease of the nervous system, patients will appear memory loss, language disorders, unresponsiveness, lost, mental behavior abnormalities and other phenomena, and even if they do not know their loved onesData show that 50 million people worldwide will suffer from Alzheimer's disease in 2018, with an average of one in three secondshow Alzheimer's disease is discovered? In 1905, German psychiatrist and neuropathologist Aloisi Alzheimer found that her brain was noticeably atrophy and abnormal "sediment" deposited in brain tissue when she examined a brain slice of a 55-year-old female dead patient who had been following her long-term observation, Oskast Detl, according to DrYu Jintai, director of neurology at Huashan Hospital, aFudan UniversityThe patient had obvious memory loss, severe paranoia and other symptomsIn 1910, the medical community named the unprovoked case after DrAlzheimer'sAccording to Yu Jintai, there are only a few drugs that can partially relieve symptoms and there is no way to stop the disease, let alone cure ithowAlzheimer's disease is triggered? According to Yu Jintai, Alzheimer's disease is a neurodegenerative disease characterized by the gradual deposition of extracellular beta amyloid protein (A beta) in the brain to form an aging spot and the excessive phosphorylation of tau protein in the cell to form neuroprogenite fibrous entanglementIt is family and distributive Less than 5% of the family Alzheimer's disease is mainly caused by mutations in related genes such as APP, PS1 and PS2; recent, there is evidence that microbial infections may also play a very important role in the onset of Alzheimer's disease New research by Yu's team shows that regulated risk factors such as obesity, high blood pressure, diabetes, smoking, and alcohol abuse also increase the risk of Alzheimer's disease, while education, good sleep, healthy eating, and active exercise can reduce the risk of Alzheimer's disease, which could provide the possibility of future prevention of Alzheimer's disease designed to remove antibodies from Tau tangles
the school's researchers have set their sights on the accumulation and deposition of Tau protein, according to UNM's official website Tau protein is a stable structure within neurons, but it can be entangled into a long clump, the ability to communicate between neurons, leading to memory loss, aphasia, like being in the fog of memory, can not see the time now that the "enemy" has been found, it is possible to cure Alzheimer's disease if the protein is targeted with precision Led by Dr Kieran Basca, an associate professor in the Department of Molecular Genetics and Microbiology at UNM, the team used viral-like particles (VLPs) to design a new vaccine They found that when the vaccine was injected into the mice, they produced antibodies that removed tau protein from the brains of the mice, a reaction that lasted several months researchers tested the mice in a series of maze experiments The results showed that vaccinated mice performed significantly better than unvaccinated mice, and magnetic resonance imaging scans showed that the vaccinated animals had less brain atrophy, suggesting that the vaccine prevented neuronal necrosis "These findings seem to suggest that we can use our own immune system to make antibodies against these tangles, and that these antibodies can actually bind and remove these tangles," said Nicole Mafelts, a Ph.D candidate and lead researcher in the Maphheth also found a significant reduction in entanglements in the cerebral cortex , the most advanced center that controls the movement of the body , and in the hippocampus , which is thought to be part of the brain and the center of emotion and memory "These results confirm that the use of vaccine intervention targeting Tau tangles can repair memory damage and prevent neuronal death, giving humans a dawn of passage through the fog of memory," he said "
it will take some time for a human vaccine to come out
" but achieving some efficacy in laboratory mice does not mean that a human vaccine will be available soon Yu stressed: "Whether the A-beta vaccine or the Tau vaccine, there is a common problem: in animal models can often show better results, but into human clinical trials often less effective." This is mainly related to the complexity of Alzheimer's disease, the relevant Alzheimer's animal models often use genetically modified mice, a single genetic background, pathological performance is simpler, and the real world Alzheimer's disease patients, both the pathogenesis and pathological performance is more complex than the genetically modified animal model , unM said in a statement that while the Baaska team also hopes to develop a vaccine for Alzheimer's disease in humans, they acknowledge that the vaccine could take decades and cost a fortune.