Am J Clin Nutr: Changes in the concentration of trace elements and inflammatory serum biomarkers in the body after noel virus infection.

The study, which aims to assess the status of micronutrients and the need to determine the effects of inflammatory and acute phase reactions on nutrient biomarkers, was published online in Am J Clin Nutr.
In the Noel Virus Human Challenge study, the researchers aimed to simulate the inflammatory response of C-reactive protein (CRP) and α-1-glucosin (AGP) through the state of infection, simulate the dynamics of micronutrient biomarkers through inflammatory states, and assess the association between noruvirus inflammation and micronutrient biomarkers 0 to 35 d after exposure.
study included 52 healthy adults and followed them for long periods of time; all were exposed to noel virus and half were infected.
post-mortem analysis of inflammatory and nutritional biomarkers was carried out.
subjects were layered according to inflammation caused by noel virus exposure.
smooth regression model analyzed the dynamics of CRP and AGP by infection status and nutritional biomarkers by inflammation.
using linear mixed effect models to analyze the independent relationship between CRP, AGP and iron, vitamin A, vitamin D, vitamin B-12, folic acid and other biomarkers from norovirus exposure 0 to 35 d.
results showed that the peak concentrations of CRP (16.0 (7.9-29.5) mg/L) and AGP (0.8-1.2) g/L in subjects infected with noruvirus occurred on the 3rd and 4th days after exposure, respectively.
The nutritional biomarkers (P<0.05) in the inflammatory group that are different from the baseline are ferritin (3rd day elevation), heparin (2nd and 3rd day elevation), serum iron (2-4th day decrease), transirin saturation (2-4th day decrease) and retinol (3rd, 4th, 7th day decrease).
of nutritional biomarkers did not change with time in the unrepentant group.
in mixed models, CRP was associated with ferramine (positive) and serum iron and retinol (negative, P<0.05).
In summary, the results of this study show that the use of experimental infectious challenge models in healthy adults, norovirus infections that cause time-restrictive inflammatory responses associated with changes in serum concentrations of certain iron and vitamin A biomarkers, confirms the need to consider adjusting these biomarkers to address inflammation when assessing nutritional status.
.