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Superoxide dismigase (SOD)
SOD acts as a catalytic enzyme in the process of hydrogen ions reacting with superoxides to produce hydrogen peroxide and oxygen. Manganese-containing (MuSOD) is among human mitochondrials, while plasma is copper-containing (Cu) and zinc-containing (Zn) SODs. It is also believed that there are three other types of SOD present outside the cell.
mitochondrials can metabolize more than 95% of the oxygen in cells, but due to the lack of hisoproteins, so the oxidative stress caused by superoxides and so on is relatively weak, and MuSOD will play an important role in such defense mechanisms.
more reported parkinson's disease patients, its > MuSOD show diversity, and MuSOD activity decreased can be seen in congenital muscular dystrophy and many other genetic diseases, especially for neurodegenerative diseases of great importance to researchers. It has been found that in diabetics who are also degenerative, their white blood cells also show low MuSOD activity.
oxidative stress refers to highly active molecules such as reactive oxygen in the body when the body is subjected to various harmful stimuli Reactive oxygen speciesROS and reactive nitrogen free fundamentals (reactive nitrogen speciesSRNS) produce excess oxidation beyond the oxide removal oxidation system and antioxidant system imbalance resulting intissuedamage.
in the process of oxidative stress, due to the threat of oxidation of free fundamentals, the various substances that make up cellular tissues such as lipids, sugars,protein >< |
oxidative stress is roughly divided into three categories:
1) as measured by reactive oxygen repair thecompound ;
2) determines the amount of reactive oxygen elimination system enzymes and antioxidants,
3) determines oxidative stress indicators containing transcription factors.
According to the type of substances of oxidative stress, it can be divided into protein oxidation damage marker detection, lipid peroxide marker detection, nucleic acid DNA/RNA damage detection and reactive oxygen elimination system enzyme and antioxidant substance detection.
Cell BioLabs, a leading U.S. cell products company, offers you complete cell oxidation stress analysis solutions that include protein carbapenemization, nitrosylation damage, and late oxidation protein product (AOPP) analysis, lipid peroxide markers terpene (HNE) and acetaldehyde (MDA), and 8-isoproporine > F2a rapid detectionRoutine damage analysis of nucleic acid DNA/RNA, such as 8-OHdG/8-OHG and AP bit detection, also includes cell-level comet analysis and
DNA double-stranded fracture analysis kits;
During oxidative stress, the role of free fundamentals on proteins includes protein peptide chain breakage The protein molecules interconnect polymerization, proteinamino acids oxidation deamination reaction, oxygen free-type attack protein reductive group, lipid oxidation cracking produced by acetaldehyde and protein amino production molecules, etc.
there are two main detection indicators for protein oxidation damage, namely protein carbide production (carboxylization) and tyrosine production (tyrosine nitrate in protein).
Cell BioLabs to provide you with a complete protein oxidation damage detection program, its OxiSelect? Protein Carbonyl Assay Kits (Protein Glycosylation Analysis Kits) are designed to quickly detect the degree of niobium-based protein
oxidative stress; Protein Nitration(Nitrotyrosine) Assay Kits (Protein Nitrosification Analysis Kit) provides a convenient solution for detecting nitrosification reactions in proteins in cells; AOPP Assay Kits (late oxidizing protein product analysis kit) can quickly detect the damage consequences of protein oxidation.
Lipid Peroxidation Analysis
Lipid Peroxidation occurs in animals and plants and has been used as a reaction marker for cell and tissue oxidation stress. Lipid peroxide is the lipid peroxidation reaction of large molecular substances such as polyunsaturated fatty acids and nucleic acids associated with phospholipids, enzymes and membrane ligands in biofilms.
form lipid peroxide products (lipid peroxide LPO) such as acetaldehyde (MDA) and 4-hydroxyproxylede (HNE), which results in changes in cell membrane mobility and permeability that eventually lead to changes in cell structure and function. 4-hydroxypropylene (HNE) and propylene dehyde (MDA) are the end product of lipid peroxidation of two powerful forces and are often used as indicators to determine lipid peroxidation.
West Meijie recommends cell oxidation pressure detection for Cell BioLabs, a renowned U.S. cell reagent specialist, which includes lipid peroxidation analysis testing reagents in addition to classic lipid peroxidation indicators 4-hydroxyproxyde (HNE) and acetaldehyde (MDA) Rapid ELISA detection and quantitative analysis of MDA based on TBRS (thiobarbiturate reactants), as well as ELISA analysis kits for important lipid peroxidation detection indicators 8-isoprene F2a during atherosclerosis formation, rheumatoid arthritis, and cancerous changes. (Responsible Editor: King Kunlun, Great Han)
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