Analysis of factors affecting the production efficiency of pelletizer

It is a common phenomenon in the pharmaceutical industry that the surface of drug particles is not smooth, the hardness is low, it is easy to be broken and the powder content is high, which will lead to the output not meeting the expected design requirements In addition, due to the problems of process arrangement and operation technology of granulator in many raw material pharmaceutical plants, the production efficiency of pharmaceutical equipment will also be affected In the process of pelletizing, there are many main reasons that affect the production efficiency of pelletizer Today, I will summarize and sort out for you: first, the influence of raw material factors The factors of raw materials directly affect the effect of granulation The materials with high starch content are easy to be gelatinized by steam After being tempered, these raw materials have certain viscosity, which is conducive to the formation of particles From the perspective of pelletizing, it is characterized by fine crushing and high pelletizing strength, but with more steam, it is easy to block the machine if a little attention is not paid, and the raw material is crushed too fine, resulting in high power consumption for crushing When the particles are too coarse, it will increase the wear of the ring die and the press rod, which will make it difficult to form the particles, especially the small-diameter ring die, and cause the poor gelatinization effect of the materials, resulting in high material consumption, low output and high powder content of the particles Secondly, the production efficiency of the granulator has a great relationship with the feed flow control In order to make the granulator work at full load without stopping, the material flow into the granulator must meet the needs of granulation, and the feeding structure must effectively eliminate the intermittent phenomenon of feeding caused by caking When the production efficiency of pelletizer is abnormal in many pharmaceutical factories, they are only busy finding the reasons in the pelletizer itself, but ignore the factors of incoming materials In fact, the production efficiency decline is caused by the unstable flow of incoming materials in many times At the same time, the ring mold also has a great impact on the production efficiency of the granulator Whether the raw material can be extruded through the die in the granulation process depends on the pressure and friction force that can be generated in the die hole This is related to the friction coefficient between the material and the die wall, the moisture content, the particle size of the material, the temperature, the buffer time of the plastic deformation part of the material and the compressibility of the material These characteristics are closely related to the hole depth and the hole diameter of the die Therefore, when raw material manufacturers produce different specifications and varieties of granular materials, the ratio of ring mold aperture will be different In addition, the production operation also greatly affects the production efficiency of the granulator Control the gap between pressing roller and pressing die correctly The gap between roller and die is too small, the die and roll are easy to wear, and the super noise is large; if the gap is too large, the extrusion of API will be affected Taking the new mould roll as an example, it is observed visually that the pressing roll seems to be on the other side, but when there is no material, it is appropriate that the main machine can not drive the pressing roll when rotating the pressing die It is specially emphasized that the new mould should be equipped with new rolls, and the gap should be smaller It is worth mentioning that in the initial blanking, do not rush to add steam, because at this time, the material is small, and it is difficult to add steam to the desired amount, and the steam is large, and the material is small, which is very easy to block the machine It is not as safe as adding steam when the material is added to a certain amount In addition, before the granulator stops working, it is necessary to add oil-based materials to the die to prevent the materials in the die from hardening, so that the next time the machine is started, the die can be ejected smoothly In the pharmaceutical industry, the production efficiency of the equipment has a great influence on the pharmaceutical process Therefore, the pelletizer production enterprises should recognize the constraints, and pay attention to avoid during the reproduction In addition, the pharmaceutical enterprises should also operate correctly, reduce the waste of materials as much as possible, and expand the production efficiency of the pelletizer.