Analysis of the application of microbial fermentation in the study of Chinese medicine

With the improvement of human living standard, the demand of human medicine has also increasedTraditional Chinese medicine processing and refining technology, such as frying, boiling, steaming and other methods can not meet the needs of modern human lifeAt present, the development of a new technology of Chinese medicine concocted, that is, through microbial fermentation methods to concoct Chinese medicineThe technology is based on microbial fermentation, making full use of the powerful transformation ability of microorganisms, the active ingredients of Traditional Chinese medicine can be highly refined, toxicity can be reduced, and the active ingredients in the medicinal materials and waste slag can be greatly separated, making the fermentation of the liquid concentration is higher, easier for the human body to absorbIn addition, due to the degradation and transformation of microorganisms, some components of Chinese herbal medicine may also have the potential to be converted into new ingredients, these new ingredients may optimize the original effect of the medicinal material on the one hand, on the other hand may have a new effectIn view of the above advantages, microbial fermentation technology to cause the Chinese medicine industry to attach great importance tofirst, microbial fermentation concocted Chinese medicine categoryaccording to the use of different methods, microbial fermentation method concocted Chinese medicine can be divided into two categories:(1) dessalator, that is, after the concocted liquid contains a certain amount of residue, need to be filtered, screening and other methods to be used;microbiological method concocting Chinese medicine according to the fermentation method can also be divided into two categories:(1) liquid fermentation, this way from the traditional method of antibiotic manufacturing experience, the use of certain and Chinese medicine ingredients can produce an effective effect of the microbiome and Traditional Chinese medicine material mixed evenly, and then placed in a container, to give suitable light External conditions such as humidity and temperature make it fermented,(2) solid fermentation, which uses agricultural products with high nutritional substances as fermentation matrix, mixes specific fungi or fungal groups evenly with them, and then gives suitable external conditions such as light, humidity and temperature for fermentationin contrast, liquid fermentation drug active ingredients are higher, and easy to control, with the possibility of large-scale automated production, solid fermentation because in the fermentation process not only produced a large number of fungal bacteria, but also accompanied by many secondary production, so the way produced liquid needs to be separated before can be usedthe superiority of the second, microbial fermentation processtraditional methods of frying, boiling and so on not only low degree of refining, but also many active ingredients with the slag were discarded together, resulting in waste, in addition to the harsh refining conditions and destroyed part of the active components, and produced a large number of pharmaceutical residues, pollution of the environmentThe microbial fermentation process fermentation conditions are moderate, so that many of the ingredients in the drug are not destroyed, and the degree of refining is high, and the production of relatively small residue, and with the help of the powerful transformation of microorganisms, but also may produce some new pharmaceutical components, these new components may produce greater efficacy, and microbial degradation can also effectively reduce the toxicity of some Chinese medicine 1, decomposition of the drug's macromolecule stakes, making the drug more easily absorbed a large number of experiments have proved that the secondary production of microorganisms is the main component of the role of Chinese medicine on the human body, because many components in Chinese medicine because the structure is too complex and not easy to be directly absorbed by human cells, and the subproduction produced by microbial fermentation can be broken down into small molecular substances, making it easy to be absorbed by the human body Therefore, the microbial fermentation process can improve the proportion of active ingredients of Chinese herbal medicine, so that the efficacy of traditional Chinese medicine is faster and better In addition, microorganisms may also increase the concentration of active ingredients of Traditional Chinese medicine, making the efficacy of Chinese medicine more obvious 2, reduce the toxicity of the drug, so that the human body can safely use Chinese medicine pay attention to "poison", is not to take toxic Chinese medicine materials directly to patients, but the need to first reduce the toxicity of medicinal materials to the range that the human body can safely accept, and then can be used This important toxicity reduction process is largely dependent on microbial degradation Microbes have a powerful decomposition and transformational effect, so that the toxicity of drugs can be greatly reduced, so that the human body can be safely used 3, improve the synthesis rate of active ingredients, to solve the situation of oversupply in many Chinese medicine materials, its active ingredient content is low, and the molecules are more complex, even if the use of high-tech is difficult to synthesize, so many Chinese medicine in short supply Microbial fermentation can effectively solve this difficult problem Microbes can produce a series of active enzymes during fermentation, which are key elements of the synthesis of active ingredients in Traditional Chinese medicine Therefore, we can use high-tech technology to implant these active enzymes into the genes of Chinese herbal materials, modify the process of gene expression, so as to accelerate the synthesis of active ingredients, more active ingredients, to solve the situation of the shortage of expensive Chinese herbal medicine In addition, we can control and adjust the expression of Chinese herbal genes by implanting specific genes to obtain the active ingredients we want , the microbial fermentation technology used in the preparation of traditional Chinese medicine can not only make the effective ingredients of Chinese medicine greatly improved, easier to absorb, but also can moderately reduce the toxicity of toxic herbs, so that humans can safely use, but also through the implantation of enzymes to modify the gene expression of Chinese medicine, improve the synthesis rate of active ingredients, to solve the tension of scarce medicinal herbs, so the process to be subject to large-scale testing Driven by this process, China's traditional Chinese medicine industry will also flourish, into the ranks of the world's medicine, for the health of all mankind better service