Analysis of the surface of human skin using a non-invasive sampler.

Volatile organic compounds (VOCs) and semi-VOCs on the surface of the human skin are hot issues in the field of metabolomics, diagnostics, skin microbiome, and human-vector mosquito vector stakes!----mosquito vectors use chemical cues to find their hosts, and human attraction to mosquitoes can be chosen based on the chemical characteristics of their skin, mosquitoes prefer to bite certain parts of the human bodyin the study, researchers looked at chemical differences in the contours of the skin surfaces of 20 volunteersuse a passive, non-invasive approach to sampling the skin surface areas of the wrist and ankleuses an in-house-developed polydimethylsiloxane (PDMS) passive sampler to concentrate skin VOCs and semi-VOCs, and then uses integrated gas chromatography-flight mass spectrometry (GC-tofms) technology to perform thermal lysuction directly at the gas chromatography intakefrom a wide range of chemical compounds are detected and identified as contributing to different surface skin chemistry profilesstudy found that 4-tetrahydronephthalene 5-Ethyl-1, 2, 3, 1' - oxybisoctane, 2 - (dodecyloxy) ethanol, alpha, alpha-dimethylbenzene methanol, salicylic acid methanol, 2, 6, 10, 14-tetraemethyleceadecane, 1, 2-benzene dicarboxylic acid, biesters (2 - methylpropyl), 4-methylbenzi, 2, 6-diisopropylnaphthalene, palmic acid and cesium-oxobefenanoic ethyl acid is closely related to human attraction and considered to be attractive to mosquitoesin addition, biolead compounds as potential lures or mosquito repellents for vector control strategies were initially identifiedresults increase current understanding of the chemical composition of human skin and show the potential to investigate mosquito vector interactions with the host using non-invasive sampling methodsWooding, Rohwer, Naud? (2020) Chemical profiling of the human skin surface for malaria control a non-sororptive sampler with GC x-TOFMSAnalytical and bioanalytical chemistry Source: MedSci Original !-- Content Presentation Ends - !-- Determine Stoding Ends.