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Ann Intern Med: Long-term use of fast-acting promethazine does not slow down the clinical progression of early Parkinson's disease

 Last Update: 2021-04-16
 Source: Internet
 Author: User

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Studies have shown that dihydropyridine calcium channel blockers may be associated with a reduced risk of Parkinson's disease (PD).

The 57 Parkinson’s research team sites in North America included patients with early Parkinson’s disease (duration <3 years) who were not taking dopaminergic drugs at the time of enrollment and were randomized to receive 5 mg promethazine or placebo twice a day.

A total of 336 patients were randomized (mean age 62 years [SD, 9]; 68% were male; disease duration 0.

After adjusting the average of least squares, the total UPDRS score changes of promethazine and placebo recipients under the anti-Parkinson drug ON state within 36 months were 2.

In summary, the results of this study show that long-term use of fast-acting promethazine cannot slow down the clinical progression of early PD.

Original source:

Parkinson Study Group STEADY-PD III Investigators.

Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial

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