ANN NEUROL: Cancer patients have higher blood coagulation markers and are susceptible to ischemic stroke

It is estimated that 4-20% of patients with ischemic stroke have cancer, and the comorbidity rate of these diseases is increasing
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This may be due to recent improvements in cancer treatment that have prolonged the survival of patients

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It is estimated that 4-20% of patients with ischemic stroke have cancer, and the comorbidity rate of these diseases is increasing
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In order to improve the understanding of the mechanism of ischemic stroke in cancer patients, Babak Navi Babak Navi and others conducted a prospective study on the mechanism of ischemic stroke in cancer patients (most cancers), comparing active cancer patients with ischemic stroke and simple ischemic stroke Pre-designated hematological markers of coagulation, platelet and endothelial activation, and embolic disease between stroke patients and patients with simple active cancer.

This study explored the pathophysiological characteristics of ischemic stroke combined with cancer

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This study explored the pathophysiological characteristics of ischemic stroke combined with cancer

From 2016 to 2020 , the research team conducted a prospective cross-sectional study in two hospitals
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The levels of all studied biomarkers differed among the groups

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The levels of all studied biomarkers differed among the groups
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The study found that compared with the control group, patients with active cancer and acute ischemic stroke had higher coagulation, platelet and endothelial cell activation markers, and more circulating microemboli

Future research should evaluate whether these biomarkers can predict the risk of stroke and recurrence in cancer patients and the response to antithrombotic therapy

Original source

Mechanisms of Ischemic Stroke in Patients with Cancer: A Prospective Study.

Ann Neurol.

Mechanisms of Ischemic Stroke in Patients with Cancer: A Prospective Study.
Ann Neurol.
2021;90(1):159-169.
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