Ann Neurol-Cerebrospinal fluid bone marrow microvesicles can effectively predict the prognosis of multiple sclerosis

Multiple sclerosis (MS) is a central nervous system itself immune demyelinating disease characterized by a wide heterogeneity

There are two entities in the earliest stages of the demyelinating spectrum of the central nervous system: Clinical Isolated Syndrome (CIS) and Radiological Isolated Syndrome (RIS)

At the same time, the activation of microglia is related to the disease progression of PMS

Microvesicles (MVs) are extracellular vesicles released by different types of cells (including bone marrow cells) in biological fluids

They included: 601 discharged patients diagnosed with neuroinflammation, neurodegenerative disease, or no neurological disease

Compared with neurodegenerative diseases and the control group, CSF bone marrow microvesicles in patients with neuroinflammation are elevated

Microvesicles can distinguish the relapse-remitting group from the control group (ROC curve, AUC=0.

In addition, microbubbles are an independent predictor of the prognosis of the relapse-remitting group and the progression group

This study confirmed that CSF bone marrow microvesicles are a clinically significant biomarker of neuroinflammation and microglia/macrophage activity in the body