Ann Neurol-Fully automatic speech analysis, may assist Parkinson's diagnosis

Given that scientists are currently exploring therapies to slow down or even stop neurodegenerative diseases such as Parkinson's disease (PD), it is becoming more and more critical to obtain sensitive and reliable quantitative progress biomarkers to determine the efficacy of such therapies
.

The best time to introduce a treatment that changes the condition may be the prodromal period
.

Idiopathic or isolated rapid eye movement sleep behavior disorder (iRBD) is a precursor of synaptophyses.

Half a century ago, Darley and colleagues pointed out in their landmark study that most patients with PD will have dyskinesias, which are mainly monophonic and monophonic (helping to reduce stress), and inaccurate consonant pronunciation , Inappropriate silence, harsh voice and insufficient time to speak
.

Recent evidence based on the Czech language suggests that subconscious speech abnormalities in iRBD patients can be detected by objective acoustic analysis

diagnosis

The phonemic differences between different languages ​​pose considerable practical challenges to the development of a unified language evaluation framework
.

This variability is limited by a set of universal principles

Therefore, language with more complex consonants may pose more challenges for PD patients
.

Most of the existing evidence about PD language dysfunction is based on single language assessment.

Therefore, it is crucial to confirm the stability of speech assessment from longitudinal studies of the duration associated with the clinical trial timeline

They conducted a multi-center study across Czech, English, German, French and Italian in 7 centers in Europe and North America
.

A total of 448 participants (337 men) were recorded, including 150 iRBD patients (the average duration of iRBD in different language groups was 0.
5-3.
4 years), and 149 patients with PD (the average duration of disease in different language groups was 1.
7-2.
5 years) And 149 healthy controls; 350 of them completed a 12-month follow-up

They found no language differences that affect the clinical phenotype of Parkinson's disease
.

Compared with the control group, iRBD (p = 0.

002) and PD (p <0.
001) were significantly abnormal in the overall acoustic language severity measurement by the composite articulation index

iRBD (p = 0.
002) and PD (p <0.
001) were significantly abnormal in the overall acoustic language severity measurement by the composite articulation index

During the 12-month follow-up, slight progress was found in the overall acoustic language impairment in the iRBD (p = 0.
04) and PD (p = 0.
03) groups
.

The novelty of this study is that automated speech analysis may provide a useful additional biomarker for Parkinson's disease for assessing disease progression and therapeutic intervention
.

Automatic speech analysis may provide a useful additional biomarker of Parkinson's disease for assessing disease progression and therapeutic intervention
.

Automatic speech analysis may provide a useful additional biomarker of Parkinson's disease for assessing disease progression and therapeutic intervention
.

Original source:
Rusz J, Hlavnička J, Novotný M, Tykalová T, Pelletier A, Montplaisir J, Gagnon JF, Dušek P, Galbiati A, Marelli S, Timm PC, Teigen LN, Janzen A, Habibi M, Stefani A, Holzknecht E , Seppi K, Evangelista E, Rassu AL, Dauvilliers Y, Högl B, Oertel W, St Louis EK, Ferini-Strambi L, Růžička E, Postuma RB, Šonka K.
Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease.
Ann Neurol.
2021 Jul;90(1):62-75.
doi: 10.
1002/ana.
26085.
Epub 2021 May 7.
PMID: 33856074.

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