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Ann Neurol-New study finds genetic risk sites for cluster headaches

 Last Update: 2021-08-03
 Source: Internet
 Author: User

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Cluster headache (CH) is a primary headache disease characterized by strong unilateral orbital, supraorbital, and/or temporal pain, lasting 15-180 minutes, and accompanied by symptoms of autonomic nerves on the same side and / Or irritability
.

Most patients have paroxysmal CH.

Current treatment strategies include suspension of acute episodes, aims to prevent reduction in seizure frequency of treatment

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They found that four independent locus (loci) (r2<0.

1) are associated with cluster headache and have genome-wide significance (p<5×10-8), rs11579212 (OR=1.
51), rs6541998 (OR=1.
53) , Rs10184573 (OR = 1.
43) and rs2499799 (OR = 0.
62, 95% CI 0.
54-0.
73, close to UFL1/FHL5), together explain 7.
2% of the phenotypic variation

The important significance of this research is that the genetic risk site of cluster headache was discovered and replicated through GWAS , and its effect size is larger than that usually seen in complex genetic diseases
.

Through GWAS , the genetic risk locus of cluster headache was discovered and replicated, and its effect size is larger than usually seen in complex genetic diseases
.

Through GWAS , the genetic risk locus of cluster headache was discovered and replicated, and its effect size is larger than that usually seen in complex genetic diseases

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