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Guillain-Barré syndrome (GBS) is a post-infectious inflammatory disorder of the peripheral nervous system that is often complicated by respiratory insufficiency
.
Approximately 10-30% of patients with Guillain-Barre disease require mechanical ventilation during the course of the disease
10-30%
Early prediction of respiratory insufficiency in GBS patients is important to properly triage patients to the appropriate level of care (i.
e.
This regional difference was recently demonstrated by Alex Y.
Doets et al.
of the University Medical Center Rotterdam, describing the first 1000 patients included in the International GBS Outcomes Study (IGOS)18
Of the 1023 eligible patients (Europe/North America n = 842, Asia n = 104, other n = 77), 104 (10%) required mechanical ventilation within the first week of study entry
.
The area under the curve value of all validation subgroups was ≥0.
80
The observed mean proportion of mechanical ventilation was lower than predicted risk: 10% vs 21% in the full cohort, 9% vs 21% in Europe/North America, and 17% vs 23% in Asia
.
After recalibration, predicted risks for the entire cohort and Europe/North America matched the observed proportions
.
This prospective international cohort study validated the Erasmus Guillain-Barre Syndrome Respiratory Insufficiency Score and showed that the model can be used for the full range of Guillain-Barre Syndrome patients
.
In addition, a more accurate, region-specific version of the model was developed for patients from Europe/North America
Erasmus Guillain-Barre syndrome respiratory insufficiency score validated
Original source:
Doets AY, Walgaard C, Lingsma HF, et al.
International validation of the Erasmus GBS Respiratory Insufficiency Score.
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