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International pharmaceutical giants such as AstraZeneca have developed new crown vaccines that have attracted attention
.
However, for Merck, which is also a giant, there has been no significant progress in the development of drugs against the new coronavirus
Mopivir is an oral antiviral drug
Molnupiravir, before today, has always had this English name, here we can transliterate it as: "Mopivir", which is more convenient for everyone to understand
.
Mopivir also has a compound name: EIDD-2801, which is mainly used in preclinical related research of drugs
Figure 1 Molecular formula of Molnupiravir
Mopeville can reduce the death rate of the new crown
Mopivir was originally designed as a flu drug, and even used clinically as a flu drug
.
And, there are preliminary data showing that Mopevir can treat COVID-19 infection
Moupivir's oral dosage regimen
In current clinical trials, the dosage regimen of Mupivir is: 400 mg twice a day, without hospitalization, directly applied to outpatients
.
The subsequent patient follow-up time is scheduled on the 5th, 10th and 15th day after treatment, and follow-up will be carried out in the hospital
Advantages of using oral drugs to treat the new crown
Generally speaking, most acute viral infections are self-limiting diseases and do not require treatment.
The human body's immunity will automatically adapt and clear or accept the invasion of the virus
.
Therefore, the treatment of acute viral infections is very different from chronic infections (HIV, hepatitis B virus, hepatitis C, etc.
Nevertheless, there is still a class of small molecule antiviral drugs that have achieved decisive efficacy in acute infections
.
Herpes simplex virus encephalitis is a very aggressive disease, with a mortality rate of over 70%, a short onset time and rapid death
summary
In short, Mupivir is a new type of potent ribonucleoside analog, which can inhibit the replication of a variety of RNA viruses including SARS-CoV-2
.
If patients can be treated with mupviril in the mild stage of the disease, the spread of the new coronavirus can be controlled , and the further deterioration of the disease can be prevented on a large scale, ultimately reducing the burden of disease on the medical system
