Anti-intracellal bacterial infection immunity

the relationship between pathogenic bacteria and host cells, bacteria can be divided into extracellular bacteria and inocular bacteria. Most of the human pathogenic bacteria are extracellular bacteria, which live in
tissue
the host cell. Cytobacteria are divided into both inocellal bacteria and specialized inocellal bacteria. The former live and reproduce in host cells, and can also survive and reproduce in vitro in a cellless environment. Specialized endocytobacteria must survive and reproduce in cells, whether in vivo or outside the body. The main infectious and intracellular bacteria are Bacillus tuberculosis, Mycobacteria bovine, Leprosy, typhoid, paratychlobacteria, Brucylobacteria, Legionella pneumoniae, listeria, monocytes, etc.
they are mainly housed in monocytes/devouring cells. The range of leprosy living cells is very wide, including neural cells; monocyte Listeria is often infected with liver cells; and TB bacteria can infect a variety of mammalian cells in vitro, but only in the body. Specialized cytobacteria have leukosomes that cause typhoid fever, sepsis, Q-hot Cox's body, errhoeal, chrysanthema of veneer lymphoma, etc. They are mainly found in non-professional devouring cells such as host endoblasts and endocysts, and can sometimes be found in monocyte devouring cells.1． Anti-cytobacteria inherent immunity
M can devour intracellulocytobacteria, but because most of the cytobacteria have the function of escape devouring and killing, so M stoic bacteria can not be cracked, but lead to the hidden and spread of bacteria, such as TB infection caused by chronic granuloma has a large number of infection with Bacillus tuberculosis M. However, after the activation of endocrine bacteria, M can secrete IL-12 and activate NK cells, NK cells bear an important early anti-cytobacterial defense function, can effectively kill and control cytobacteria infection. Activated NK cells produce IFN-γ, which in turn activates the sterilization function of M.2． Anti-cytobacteria adaptive immunity
insexual
antibodies
can not enter the cell and cytobacteria, the removal of intracellular bacteria protective immune response mainly depends on cellular immunity. Among them, IFN-γ secreted by CD4 Th cells can energize the sterilization function of M, CD8 CTL can effectively kill infected cells, so that the cytobacteria release, and then by antibody and other conditioning by M s devoured to remove. IFN-γ and TNF are important for fighting TB or monocyte-producing listeria infections.
In the anti-cytobacterial immune response, the activation of M-activated secretion
cellular factors
and Thl can also induce DTH reaction, resulting in damage to host tissue and the formation of chronic granuloma. Granuloma can limit the inflammatory response and control the spread of germs, but cause tissue necrosis and fibrosis, serious damage to tissue.