Antibacterial activity of N-alkyl mide-based poly (ionic liquid) nanoparticles

The researchers recently synthesized alkyl mimi-based PIL with simple free-form polymerization and systematically studied the antibacterial activity of the corresponding PIL nanoparticles.
obtained by the PIL nanoparticles against E. coli (E. coli) and Staphylococcus aureus (S.a... Excellent antibacterial activity.
(Ionic Liquid) (PILs) can be self-assembled into polymer nanoparticles with a highly ordered internal structure, making them potential candidates for antimicrobial agents because they have highly concentrated local charges . However, there has been little research on the antibacterial application of self-assembled PIL nanoparticles. In a new study, PIL based on alkyl metazole was synthesized from simple free-form polymerization, and the antibacterial activity of the corresponding PIL nanoparticles was systematically studied. These obtained PIL nanoparticles exhibit excellent antibacterial activity against E. coli (E.coli) and Staphylococcus aureus (Staphylococcus aureus).
antibacterial efficacy depends on the length of the alkyl chain
the antibacterial efficacy is obviously dependent on the length of the alkyl chain, i.e. C 12 > C 16 > C 10 > C 8, which means that the optimal alkyl chain length is required to destroy the cell membrane. In particular, the contribution of hydrophobic and charge effects to antibacterial effects is assessed by introducing negatively charged units into PIL. The hydrophobic effect is more profound than the charge effect. In addition, it has been found that the synergy of anions depends on the length of the alkyl chain of PIL. The proposed structure-antibacterial activity relationship is essential for the structural design and performance optimization of antibacterial polymer nanoparticles.
the study was published in Polymer Chemistry, 2019, Issue 2.