Anxiety may also be a problem in the gut

December 23, 2020, the Information Office of the State Council held a press conference, the National Health And Wellness Commission Director of the Bureau of Disease Prevention and Control Chang Jile revealed that in recent years, China's residents of psychological behavior problems and mental disorders gradually increased the number of people with mental health problems increasingly prominent. According to 2019 data, the prevalence of anxiety disorders in China is 4.98 percent.We generally believe that anxiety and depression are caused by imbalances in neurotransmitter traits in the brain, and traditional treatments are designed to increase the availability of those neurotransmitter in the brain or at least have some effect on them. For example, if someone suffers from depression, they will take selective 5-serotonin reuptake inhibitors to alter the availability of certain neurotransmitters in the brain. Of course, we recognize that in some cases these drugs are useful and may even save lives. However, medications often only temporarily relieve and suppress symptoms and often bring serious side effects.we should find the root cause of the problem and solve it at this level, not just suppress the symptoms. Someone gave the example of if you have a stone in your shoe that causes pain in your foot, you can use painkillers that can definitely help you relieve the pain, but obviously that's not a good solution. The best way is to take off your shoes and pour out the stones, which is the root cause of the problem., if we think about anxiety from this perspective, we should consider what causes anxiety in the first place. Even if anxiety is caused by an imbalance in the neurotransmitter in the brain, what causes these neurotransmitter imbalances? They do not lose their balance for no reason. Anxiety is not our natural state, of course, from an evolutionary point of view, anxiety is beneficial in some cases, it can let us survive, let us away from danger, this is an appropriate response. But if anxiety persists, it's not normal for us. So if a person is suffering from anxiety disorders, what exactly causes these neurotransmitter to lose their balance is a key issue that we need to address.or start in the gut long-term attention to our friends may not be surprised that the root cause we are looking for lies in our gut. Hippocrates, a Greek doctor known as the "father of medicine", once said that "all diseases begin in the intestines", and anxiety seemed to be no exception.there is a lot and growing evidence every day linking intestinal health to brain health. In fact, if we have inflammation in our intestines, parasitic infections, overgrowth of small intestine bacteria, overgrowth of fungi, or bacterium disorders, there is an inflammatory response that affects our brains, leading to inflammation of the brain and a host of other problems. Unfortunately, many psychologists or psychiatrists are unaware of the link.addition, when we think about the production of neurotransmitter, we tend to think of the brain, but the truth is that some neurotransmitter produced in the gut is much more than in the brain. In fact, the gut is called our second brain, and it is essentially a completely different branch of our nervous system, called the intestinal nervous system. So it's no wonder that there's a strong link between the gut and the brain, and that intestinal dysfunction can lead to cognitive, emotional, and behavioral disorders, not just anxiety and depression.In fact, the most popular theory of depression today is called the inflammatory cytokine model of depression, which holds that inflammation, whether it starts in the intestines or elsewhere in the body, inhibits activity in the forehead cortical layer of the brain and leads to all signs of depression. Studies have shown that gastrointestinal disorders are associated with Parkinson's disease, Alzheimer's disease, attention deficit ADHD, autism, obsessive compulsive disorder and even schizophrenia. So, really not too many cognitive, behavioral, or mood disorders are not related to intestinal problems. As the research progresses, we will find that this connection is becoming stronger and stronger., if you're suffering from anxiety, maybe you should check your gut health. Anxiety may begin in our intestines.the brain and intestines communicate?the brain and intestines interact directly through the ecstransi nerve, which connects the central nervous system to body organs such as the heart, lungs and digestive tract. The ecstic nerve can be activated by many neuroactive molecules in the intestine.neurotransmitterssome gut bacteria can synthesize neurotransmitters, including γ-aminobutyric acid, 5-oxycodone and dopamine, as well as neurotransmitter regulators, such as brain-based neurotrophic factors. In fact, more than 90 percent of 5-serotonin and more than 50 percent of dopamine are synthesized in the intestines, not in the brain.short-chain fatty acids the body itself can not digest dietary fiber, but can be fermented by gut bacteria to break down, producing anti-inflammatory short-chain fatty acids. Short-chain fatty acids can stimulate the sensory and autonomic nervous systems and are beneficial to the nervous system. One example is butyric acid, which has been shown in animal models to slow the progression of Parkinson's disease and Huntington's disease.hormones the gut bacteria are involved in the release and degradation of hormones such as insulin, gluatic glucosin, leptin and estrogen, which can affect our brain function to some extent.Other signaling moleculesneuroendocrine cells account for about 1% of intestinal endocrine cells, which release more than 20 neuroactive signaling molecules, including neuropeptide Y, oxytocin, stomach hunger and calcitonin gene-related peptides. intestinal bacteria affect our brain function throughout our lives. In the early stages of life, the implantation of gut bacteria is essential for the normal development of the brain. mice that do not have any microbes in their intestines develop mental developmental abnormalities and structural defects in the brain. Changing the gut bacteria with antibiotics or probiotics may impair or improve memory function and further support the role of the gut in brain function. In addition, there is evidence that the gut bacterium can also regulate pain, affect myelin nerve protection, and affect neuroplasticity. anxiety and other mood disorders can also be affected by the stability and diversity of the gut bacteria due to the presence of the microbial-intestinal-brain axis. Let's take a look at some evidence that supports the link between gut bacteria and anxiety. gut bacteria determine how our bodies respond to stress hypothyroidism-pituitary-adrenal axis (HPA) is the system that controls our stress tolerance and response to stress. You may have heard of the "fight or escape" response to stress, that is, in the face of stress, either choose to fight or choose to escape. For example, we walk in a dark alley, someone comes up to us, and we feel our heart beat faster, our breathing accelerates, and all these physiological reactions are preparing us to fight or escape, which is part of the HPA axis. in modern society, we have some long-term stress, such as financial pressure, interpersonal pressure, work pressure and so on. The pressures of everyday life inglight up to activate these systems. What happens when these systems are activated over a long period of time? This can lead to changes in the release of stress hormones such as dehydrodegesterone, cortisol and progesterone, which in turn affect the production of many other hormones and neurotransmitter in the body. Essentially, our stress response systems evolved in an environment of acute stress, not in the long-term low levels of sustained stress we face every day. Therefore, long-term stress can lead to disorders in our stress response system, leading to various problems. healthy intestine promotes normal stress response through the HPA axis. The intestinal bacterium is critical to the development and function of the HPA axis, and the normal development of the HPA axis function has a critical development window period, during which the intestinal bacteria must be colonized. Sterile mice exhibited exaggerated HPA stress responses, a signature feature of anxiety, characterized by excess corticosteroids and adrenal corticosteroids. This exaggerated reaction can be reversed by supplementing probiotics, but only in young mice. On the other hand, pathogenic E. coli can make this symptom worse. intestinal bacteria are involved in regulating stress response, which in turn changes the gut microbiotics. This interaction goes both ways. in mice, stress can lead to significant changes in the composition of the gut bacteria, such as mother-child separation stress early in life or prolonged bondage stress. In humans, although specific changes in bacterial composition are not exactly the same in different studies, there have been reports that stress affects intestinal function. A person's response to stress is likely to depend on their intestinal microbio, intestinal wall integrity, dietary composition, and overall health. the intestines, and you also find differences in the composition of gut bacteria in animals and humans with mood disorders. In mice, depression and anxiety were accompanied by changes in the composition of the gut bacteria. Similarly, some human studies have found differences in gut bacteria between anxious and/or depressed patients and healthy controls, as shown by an increase in some potentially harmful bacteria in patients with depression and a decrease in beneficial bacteria, and the lower the level of certain types of bacteria, the more severe depression appears to be, such as the genus fecal bacteria. intestinal bacteria disorders can lead to anxiety, and the reconstruction of intestinal bacteria can alleviate anxiety-like behavior. After infection with pathogenic bacteria such as campylobacter or citric acid, mice developed anxiety and behavioral abnormalities, possibly due to activation of the amygdala in the brain region associated with anxiety, and supplementation with probiotics seemed to reduce anxiety behavior. In another study, oral antibiotics altered the composition of the intestinal bacteria in mice, increased anxiety-like behavior, and increased expression of brain-sourced neurotrophic factors in the brain's sea mass, all of which improved within weeks of antibiotic cessation. When antibiotics were given to sterile mice, no changes in behavior or expression of brain-source neurotrophic factors were observed, indicating that intestinal cytosus was essential for these changes. same study, researchers performed a fecal transplant between mice with different behaviors in two different strains. When timid and anxious mice were planted with faeces from less anxious mice, the mice's exploration behavior increased and their anxiety decreased; It is worth noting that these behavioral changes are not accompanied by changes in neurotransmitter levels in the brain, further evidence that the factors affecting anxiety and other mood disorders extend far beyond the brain. can we improve intestinal bacteria disorders? healthy gut should have a diverse, stable and robust intestinal bacteria with high intestinal wall integrity. Unfortunately, however, many factors in modern society can damage our gut health: overuse of antibiotics
inflammatory foods such as refined sugars, refined carbohydrates, super-processed foods, etc.
insuperative dietary fiber intake
long-term stress
indulation
Caesarean section and formula feeding If you suffer from mood disorders such as anxiety, or a range of other ailments such as eczema, obesity, and gastrointestinal dysfunction, repairing the intestines may relieve some of the symptoms: eat less high-sugar refined foods
eat more dietary fiber. Dietary fiber promotes the growth of beneficial bacteria in the gut, while a diet with low dietary fiber reduces microbiobiobiosis in the gut.
To eat some naturally fermented foods, such as yogurt, pickles, pickles, natto, etc., they all contain a lot of beneficial microorganisms
proper exercise and good sleep How to maintain a healthy gut bacterium regulate the gut microbiome, so that eating healthy We know that probiotics are active microorganisms that ingest enough to have a beneficial effect on host health, and scientists refer to probiotics that are beneficial to host mental health as "psychobiotics," which we call "beneficial bacteria." human clinical trials have shown that taking probiotics can reduce stress, improve sleep quality and improve memory. In human clinical trials, Lactobacillus acidophilus, lactobacillus cheese, Bifidobacteria and long Bifidobacteria have been shown to improve anxiety and/or depression scores. It is worth noting, however, that not all probiotic clinical trials are effective for mood disorders, and that different people respond differently to the same probiotic, so it takes repeated attempts to find the probiotic that is most beneficial to them.