ANZ research may help treat sepsis
Last Update: 2020-12-08
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SYDNEY, Oct. 8 (Xinhua Guo Yang) Australian researchers recently published a paper in the British journal Nature Immunology, said they found a protein-like body played a key role in triggering an inflammatory response to sepsis, a finding that could be used to develop new treatments for sepsis.
is a disease caused by the immune system's overreaction to infection, which can lead to severe inflammatory reactions in the body, which in turn can lead to tissue death and multi-organ failure.
researchers at le Drobo University in Australia and others have found that a protein subject called TREML4 is a key regulatory factor that triggers an inflammatory response to sepsis and immune apoptosis. Experiments in mice showed that the overall survival rate of mice with sepsis increased after the protein was removed.
, an associate professor at the University of Le Drobo, said existing treatments often focus on suppressing inflammatory responses, but at the same time destroy the immune system and weaken the body's ability to fight infection. In contrast, the removal of TREML4 protein subjects is more "moderate", although there will be some inflammation, but the body's immune system is more resistant to infection.
researchers say they have found receptors in humans that correspond to TREML4 protein receptors, and the next phase will focus on developing therapeutic antibodies against TREML4 protein receptors.
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