Application and characteristics of spray drying in pharmaceutical industry

Changzhou fengneng drying domestic drying industry personality design, continuous innovation of enterprises! Spray drying has been applied in the pharmaceutical industry for decades After years of research and development, spray drying has developed from simple spray drying to multi-functional, combined and spray drying However, different types of spray drying equipment have different performances and applications The spray drying produced by Funeng drying company has absorbed advanced technology from abroad Based on the basic idea of energy and energy spray drying, this paper expounds the characteristics of the energy and energy spray drying equipment, so that people can better apply such equipment, and also make the equipment better serve the pharmaceutical industry of our country Brief description of the spray drying machine: spray slurry, such as solution, emulsion and suspension, into small droplets in hot air When it falls, water is evaporated into powder or granule products The hot air is introduced into the top of the drying tower, and the slurry is delivered to the top of the tower by the feed liquid pump After being sprayed into a mist like droplet by the atomizer, the surface area of the droplet group increases After contacting with the hot air at high temperature, the moisture evaporates rapidly, which becomes the drying product in a very short time and is discharged from the bottom of the tower Among them, the temperature of hot air contacts with the liquid drop rapidly, which causes the humidity to increase As the hot and humid exhaust gas, it is extracted by the exhaust fan, and the fine powder entrained in the exhaust gas is recovered by the separation device The whole drying process is divided into two stages: constant speed and deceleration In the constant speed stage, water evaporation occurs on the surface of the droplet, and the evaporation speed is controlled by the diffusion speed of the vapor through the surrounding gas film Its power is the temperature difference between the surrounding hot air and the droplet The larger the temperature difference is, the faster the evaporation speed is, and the water diffusion speed through the particles is greater than the evaporation speed Then, when the diffusion rate decreases and the saturation of the particle surface can no longer be maintained, the evaporation rate begins to slow down, and the drying begins to enter the deceleration stage In the deceleration stage, the particle temperature starts to rise and the drying is over, at this time, the material temperature is close to the surrounding air temperature The characteristics of Changzhou Fengeng spray dryer are: the temperature of the droplets is not high during the spray drying process, the quality of products is good, and the temperature range of spray drying is wide Even if the hot air is used, the exhaust temperature will not be high In the early stage of drying, the material temperature does not exceed the wet bulb temperature of the surrounding hot air, and the quality of the dried product is good The significance of its application in pharmaceutical industry is that it is not easy to produce protein egg change, vitamin loss or oxidation and other defects The quality of thermosensitive drugs is basically close to the standard of vacuum drying The products after the spray drying has good dispersibility, fluidity and solubility As the drying process is completed in clean air, the product can basically keep the ball shape similar to the droplet The spray drying speed produced by Funeng drying company is very fast After spraying, the surface area is increased Under the action of high temperature airflow, the moisture of 95%~98% can be evaporated instantly The drying time is usually only 10~40s (relative to 1L liquid) High energy spray drying process is simple, easy to control and suitable for continuous scale production Abundant energy spray drying is often used in materials with moisture content of 40%~60% Special materials can be up to 90% After spray drying, most of the products do not need to be smashed or screened again, thus simplifying the whole production process At the same time, the operating conditions can be changed in a certain range to control the particle size, bulk density and water content of the product In addition, because the drying products can be continuously discharged, the spray drying machine can be used for continuous scale production The spray drying machine is suitable for clean production area, because the spray drying operation is carried out in the closed tower, avoiding cross contamination and dust flying It is suitable for the production of raw materials in the pharmaceutical industry, especially the production of sterile raw materials
Spray drying is widely used in the pharmaceutical industry: spray drying can be widely used in the production of raw materials The varieties can be applied to amoxicillin, ampicillin, aspirin, dihydrostreptomycin, kanamycin, ampicillin, penicillin, tetracycline, streptomycin, chloramphenicol, sulfathiazole, vitamin A, vitamin E, vitamin B12, and chlorination Aluminum, aluminum sulfate, amylase, barium sulfate, calcium lactate, calcium pantothenate, hormone, L-lysine, niacin, protease, rutin derivative, hepatin, etc Changzhou fengneng drying Engineering Technology Co., Ltd welcome new and old customers, negotiate!