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Application of CD3 Monoclonal Antibody in Biomedicine and Clinical Immunotherapy

 Last Update: 2022-08-30
 Source: Internet
 Author: User

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01 Cluster of Differentiation CD In the field of cell biology and immunology, the term CD is an abbreviation of "Cluster of Differentiation" (differentiation cluster or group of differentiation), also known as leukocyte differentiation antigens, which are a class of proteins or glycoproteins on the cell membrane

Partially differentiated cluster (CD) number grouping

grouping	Types of CD Molecules
T cells	CD2, CD3, CD4, CD5, CD8, CD28, CD152 (CTLA-4), CD154 (CD40L), CD278 (ICOS)
B cells	CD19, CD20, CD21, CD40, CD79a (iga), CD79b (igaβ), CD80 (B7-1), CD86 (B7-2)
myeloid cells	CD14, CD35 (CR1), CD64, CD284 (TLR4)
blood cells	CD36, CD41 (Integrin αII β), CD51 (Integrin av), CD61 (Integrin β3), CD62P (P-selectin)
NK cells	CD16 (FcγRIII), CD56 (NCAM-1), CD94, CD158 (KIR), CD161 (NKR-P1A), CD314 (NKG2D), CD335 (NKp46), CD336 (NKp44), CD337 (NKp30)
adhesion molecule	CD11a-CD11c, CD15s (sLe ^x ), CD18 (integrin β2), CD29 (integrin β1), CD49a-CD49f, CD54 (ICAM-1), CD62E (E-selectin), CD62L (L-selectin)
Cytokine/Chemokine Receptors	CD25 (IL-2Ra), CD95 (Fas), CD178 (FasL), CD183 (CXCR3), CD184 (CXCR4), CD195 (CCR5)

CD3 is mainly used to label thymocytes, T lymphocytes and T-cell lymphomas.

CD3 key structure

TCR/CD3 complex structure

Teplizumab is a humanized anti-CD3 monoclonal antibody that prevents T cells from attacking pancreatic beta cells by preventing the formation of the CD3-TCR complex

Features

High purity and high safety
High activity and high stability
Humanization and cell preparation
High batch stability, available from stock

references:

[1]Deconstructing the form and function of the TCR/CD3 complex.

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