Application of pharmacopoeia standards for medicinal mannitol in the field of medicine

Application of medicinal mannitol pharmacopoeia standards in the field of medicine Mannitol is a good diuretic in medicine, reducing intracranial pressure, intraocular pressure and treating kidney drugs, dehydration drugs, sugar substitutes, also used as excipients of tablets and solid and liquid diluents
.
Mannitol injection (Injectio Mannitou), as a hypertonic antihypertensive drug, is a commonly used drug for clinical rescue, especially for the rescue of brain diseases, and has the characteristics of
fast antihypertensive effect and accurate effect required by drugs to reduce intracranial pressure.
Mannitol can improve plasma osmotic pressure after entering the body, dehydrate the tissue, can reduce intracranial pressure and intraocular pressure, after filtration from the glomerulus, it is not easy to be reabsorbed by the renal tubules, so that the urine osmotic pressure increases, brings out a large amount of water and dehydration, for craniocerebral trauma, brain tumors, edema caused by hypoxia of brain tissue, edema caused by large-scale burns, ascites glaucoma
caused by renal failure.
It can also prevent and treat early acute renal insufficiency
.
As an excipient for tablets, mannitol is non-hygroscopic, dries quickly, has good chemical stability, and has the characteristics of refreshing taste and good granulation, and is used in most tablets
such as anticancer drugs, antibacterial drugs, antihistamines and vitamins.
In addition, it is also used for chewable tablets such as decanting medicine and oral cooling
.
Although mannitol can be absorbed by the human gastrointestinal tract, it does not accumulate
in the body.
After being absorbed, part of it is metabolized in the body and the other part is excreted from the urine; Mannitol is endothermic when dissolved, has sweetness, and has a comfortable feeling in the mouth, so it is more widely used in the manufacture of chewable tablets such as sobering up drugs and oral cooling agents, and its granule type is specially used as an excipient
for direct tablet compression.
In the food field, the product has the smallest water absorption in sugar and sugar alcohols, and has a refreshing sweetness, which is used for anti-stick of maltose, chewing gum, rice cakes and other foods, and as an anti-stick powder
for general pastries.
Dibromomannitol
can be prepared by hydrobromic acid reaction.
It can also be used as a low-calorie, low-sugar sweetener such as diabetic food and bodybuilding food